On June 7, 2023, I was privileged to cover the convention of the Biotechnology Industry Organization (BIO) International Convention–my first time attending the meeting since 2018, when the 25th anniversary of the gathering was held here in Boston. The excitement was back–with 9144 companies registered to attend, many with booths, tables or pavilions–and, according to Stat News, some 15, 000 investors, executives and promoters.

On the afternoon of its third day, the convention, headlined “Stand Up for Science,” had a more fun and friendly vibe than I’d noticed at past BIO conventions.

Short on time, I wandered around the exhibition floor–chatting with exhibitors and attendees, snagging a latte, dark chocolate squares, a small nylon backpack advertising New York State Life Sciences, and a large mousepad.

I was sorry to miss many fascinating discussions: “Realizing the Promise of Gene Therapy and Gene Editing: Current Challenges, Opportunities and Trends; ” “A Price Control Odyssey: The Inflation Reduction Act’s Effects on the Innovation Ecosystem;” ” Belonging in Biotech: How to Advance Greater Inclusion Across the Biotech Workforce;” “Launching Successful Gene Therapies; Fighting Antimicrobial Resistance with Vaccine Innovation; ” “New Approaches to Oncology Drug Discovery;’ Re-imagining Drug Development and Regulatory Submissions through Cloud-Based Technologies;” “The Intersection of Cancer and Mental Health”; “Women and their Health: Fueling an Ecosystem of Scientific Innovation to Address Unmet Needs”. All of the above (and more) took place in the same hour as my first chosen panel discussion of the day: “Psychedelics…the Trip Continues.” (I viewed a streaming version because the main conference room was packed full.)

Psychedelics…the Trip Continues

Freelance journalist and broadcaster David Cox led Jeff Rolx, venture partner and portfolio CEO at 02h Ventures; Kurt Rasmussen, Chief Scientific Officer at Delix Therapeutics, Inc., and Peter Silverstone, CEO and Director of Zylorian Health in a wide-ranging discussion of the future an evolving industry projected to be worth billions of dollars, one day.

The panelists described the variety of challenges faced by the fledgling industry as it evolves from what the official writeup termed “a stigmatized counterculture” to a scientifically robust industry.

Among the challenges:

• Navigating the wide variety of regulatory systems in the US and abroad as well as attitudes of different states and national governments
• Issues involved in clinical trials given potentially dangerous side effects; measuring efficacy of treatments when placebos are not an option
• Whether the pharmaceutical industry will invest in a field with a “hippy” reputation
• Whether non-hallucinognic forms will be likelier to be used therapeutically before hallocinogenics
• How psychedelic therapeutics will get to market given the difficulty small developers may have in getting funding
• Determining what the therapy is and how it can be standardized.

“We are completely blind right now, ” said Silverstone, of Zylorian Health. “Our AI [artificial intelligence] overlords may soon tell us [what to expect]…but we are just at the beginning.” Silverstone predicted that the next three or four years will be telling for the industry, and suggested that 2024 could possibly be “a big year” for psychedelics.

Roix, of 02 Ventures described the current mental health situation as a “public health emergency,” with huge numbers of patients struggling with depression and post traumatic stress disorder. There are complex protocols and treatments and too few resources, he said. He also wondered how anyone will make money–especially if psychedlics work after just a few treatments and are not given as pills to be taken every day.

According to Silverstone, science is moving to the point where “the opportunity to deliver something novel in the field of neuroimmunology is huge.”

He predicted that the field may need to be “reformatted” to interest big pharma–“which will jump in when it’s ‘de-risked’ from safety concerns, reimbursement issues and questions about whether non-hallucinogens will work.

Rassumen of Delix Therapeutics expressed optimism that non -hallucinatory forms are possibilities. He pointed out that that compounds that enhance structural nerve plasticity are “starting to uncover how the brain changes over time”–which could, perhaps in conjunction with stem cell therapies, lead to getting back some functions in patients with dementia and other diseases of the aging brain.

He also said that treatment forms which resemble what in past would have been called “tripping” may diminish because depressed patients now seem to be more secure in carefully monitored medical settings.

When Rasmussen suggested possibly rebranding the field–that is, ” don’t call it psychedics,” Silverstone quipped, “That won’t happen.”

Life Science and the Gun Violence Epidemic

I next attended “The Life Sciences Industry: Taking a Public Health Approach to Ending the Gun Violence Epidemic,” moderated by Steve Usdin, Washington Editor and Head of Policy and Regulation at BioCentury.

The panelists included (left to right) Paul Hastings, President and CEO of Nkarta, a clinical stage biotechnology company in California; Juan Carter, outreach manager at the Giffords Center for Violence Intervention, headquartered in San Francisco and Washington, DC. [moderator Steve Usdin] ; Angus Mcquilken, co-founder of Life Sciences to End Gun Violence Epidemic and Industry Relationship Executive for Life Sciences at Boston Law Firm McDermott Will and Emery; Sharon Barber-Lui, a life sciences leader and BIO board member; and BIO CEO Rachel King.

All of the panelists said they strongly believe in gun control; King and Barber-Lui both said they had attended the Million Mom March to call for stricter gun control some twenty years ago. But most agreed that corporate lobbying for what has become a volatile political issue presents difficulties–and that individual commitment is called for.

King said that though she personally supports ending gun violence, she must adhere to the BIO directors’ decision to limit activities to those directly concerning the biotechnology industry.

Mcquilken urged attendees to join the organization he cofounded– “Life Sciences to End the Violence Epidemic”–which lobbies for stronger gun control laws. He pointed out that biotech seeks evidence-based solutions to problems–and that there is strong evidence that Massachusetts’ strict gun control laws, which require considerable training before guns may be purchased, account for the commonwealth’s relatively low rate of shooting deaths.

Hastings said that as a CE0 he has held events supporting gun control measures–but that he has been reticent to publicize photos of participants due to the negative backlash he would expect.

Carter said that it is important for health care and other professionals who work with victims of gun violence and their families to be supportive and accepting of them, lest they become dejected and hopeless when they return to troubled communities, and do not return for needed help.

Also suggested was that companies seeking to recruit youthful employees find ways to encourage activism.

An audience member who did not give his name pointed out that the Second Amendment to the Constitution, which grants certain rights to bear arms , was meant to prevent imperialism but it is now being used to promote terrorism.

Targeting Success: 3 MIT Thought Leaders on Innovation

At my third panel discussion of the afternoon, MIT’s Angela Koehler, associate professor of biological engineering; Robert Langer, David H. Koch Institute Professor, and Giovanni Traverso, associate professor, delved into questions and challenges for scientists in academic and research institutions who seek to bring their innovations to market.

In a discussion moderated by Joshua Fox of the Mintz law firm, Langer [second from left]–who is well- known as a co-founder of Moderna pharmaceuticals and has more than 400 patents licensed or sub-licensed by a myriad of companies–said that spinning a successful company out of academe requires a “breakthrough technology platform”; a really good CE0; and raising enough money. (Full disclosure: Bob is a personal friend of mine).

Koehler [left] emphasized the importance of building “connections” to raise funds and recruit a great team–and that a CEO has to be willing to “plug in a fridge”–that is, be willing to do everything.

According to Travers [second from right], ” it’s important to have a management team as outstanding as the scientific team.” When Langer’s warned not to try to leave the academic setting too early lest you wind up in “the valley of death” (unable to raise enough money), Travers recommended seeking grants and non-traditional investors such as insurance companies to take the science through clinical trials. Koehler suggested looking for disease-oriented foundations for funding.

All-in-all, BIO 2023 a fascinating convention; next time I’ll try to go to everything–which is, of course, impossible.

—Anita M. Harris
Anita Harris is a writer, photographer and communications consultant. She has authored three non-fiction books.
New Cambridge Observer is a publication of the Harris Communications Group, a PR and digital media firm based in Cambridge, Mass.

Links to
Part I Overview, Watson, analytics
Part II digital devices, long term care.
Part III Apps, devices, roadblocks

Behavioral and Population Health; Roadblocks to change

Can mobile apps really improve mental health? Cut the costs of health care? Help professionals track and care for patients? At a day-long conference sponsored  on health systems innovation organized the MIT/Sloan MIT  Initiative for Health Systems Innovation (HSI), experts from a variety of fields attempted to answer those and other questions aimed at furthering a transformation of  the US healthcare system.  Part III of a series about the conference describes apps and devices for behavioral health, personalized and long-distance care. It also discusses new state models to integrate community, health and social systems aimed at tracking and caring for patients and points out that no matter how sophisticated the technology, it is still up to human beings to make it work.

Behavioral Health

Dan Mordecai, MD, National Leader, Mental Health and Wellness at the managed care consortium Kaiser Permanente described:

• Promising mobile apps aimed at helping people prevent or overcome eating disorders, addiction, or suicide; remain on diets or exercise plans; or connect them with treating providers or coaches.
• Wearables that can measure how much people move or perform text and voice analysis to help professionals understand who needs care, months or years before it is needed.
• Predictive analytics to help prevent self-harm

While many of the above technologies have yet to be proven effective, Mordecai said, telehealth technology has been shown to be helpful in supporting and promoting long-distance health care for areas with shortages of medical personnel.  Telehealth may be carried out through videoconferencing, store-and-forward imaging, streaming media, and terrestrial and wireless communication.  

Mordecai also pointed out that with digital advances, “we are moving from individual doctor patient relationships” to a “personalized’” system, which relies increasingly on data, but that “there is a long way to go.”    Mordecai plans to use what he termed “crowd sourcing” to analyze the effectiveness of apps and other new health technologies, based on the electronic health records of Kaiser Permanente’s   nearly 12 million patients.

 

State models and population health
Analysis like that used at Kaiser Permanente is crucial for assessing treatment and cutting costs, but it is more challenging to perform outside of managed care programs, which have access to a vast array of patient records, according to Michael Wilkening, the California Undersecretary for Health and Human Services.  Analysis to records for care funded by government or private insurance is hampered by fragmented  social, health provider and  insurance systems and by legal and technical challenges of sharing patient data among those systems,

The New York State Medicaid director, Jason Helgerson, pointed out that for state Medicaid systems,  which serve mainly low-income populations,  it can be difficult to simply keep track of patients,  much less co-ordinate and evaluate their care or reduce their treatment costs.  As an example, he described a city homeless shelter that serves breakfast and dinner, but not lunch. Hungry residents regularly go to the fire station next door and complain of chest pain; they are taken by ambulance to a hospital emergency room, where they are evaluated, at high cost, given lunch, and then transported back to the homeless shelter in time for dinner.

Medicaid systems in at least several states are working on projects to prevent such situations by better integrating social services with medical and behavioral health care. Some are starting to employ analytics to recommend, monitor and measure the success of treatments, and to pay for performance rather than service.  As a result, Helgerson said, “Medicaid may be in the best position to drive change” in health delivery systems.

Roadblocks to change
Still, as a variety of speakers pointed out, despite the promise of digital innovation, there are many roadblocks to change.   Such roadblocks include: reluctance to replace or augment human decision-making with digital solutions;  complex reimbursement systems  and the need for insurer “buy-in” to pay for new technologies;  disparate stakeholders with different goals;  issues of privacy and security;   the  tendency of legislators and other policymakers to view health problems as individual rather than societal;   failure to address the lack of food and shelter that leads to poor health and expensive repeat hospital visits;  and, last but not least, cost.

In the words of Vocera’s Elizabeth Boehm, regarding systemic change, “it takes more than technology to get it done.“

And, as Restef Levi, of the Sloan School, put it: “Technology is important but…at the end of the day, health is about humans.”

 

LINKS TO:

Part I Overview, Watson, analytics
Part II digital devices, long term care.
Part III Apps, devices, roadblocks

Videotapes and photos of the conference, held November 29, 2017, are available at http://mitsloan.mit.edu/alumni/events/2017-cambridge-health-conference/

–Anita M. Harris

Anita Harris is a writer and communications consultant specializing in health science and technology.

New Cambridge Observer is a publication of the Harris Communications Group, a content and digital marketing firm based in Cambridge, MA.

Still thinking about the fabulous Georgia O’Keeffe show I saw last Sunday at the Peabody Essex Museum, in Salem, MA. “Georgia O’Keeffe: Art, Image, Style,”  is a retrospective going back to O’Keeffe’s high school years. It continues through her experiences in Chicago, Texas, New York City, Lake George, New Mexico and beyond her lifetime, to the present day.

 

 

The exhibit  features not only her art work through those years, but also year-book entries, photos of and by O’Keeffe, video of a conversation in which she says she was lucky that her work coincided with her time and was liked but that her paintings might have been better if she’d remained unknown.

Central to the show is the distinctive clothing she designed and wore–presented in relation to her paintings.

 

 

 

 

The show includes video from a 2018 fashion show in which models prance on a runway. wearing styles like those originated by OKeefe.(immediately below)

My friend E remarked on O’Keeffe as a feminist force. But while O’Keeffe was a ground breaker in the art world and is sometimes referred to as “the mother of abstract art,” a PEM commentary points out that she insisted throughout her career that she did not want to be considered a female artist…but simply an artist.

I did wonder what would have happened if famed New York City photographer Alfred Stieglitz, 30 years her senior, had not seen her work when she was a young artist and championed it–and her; if she had not moved to New York and married him; if he had not taken and shown photograph after photograph of her; if she had not had the safety and freedom afforded by Stieglitz and his family wealth in NY and Lake George. But an example of the early commercial artwork (left), on which she embarked to supplement her Texas teaching salary, makes me certain she would have become renowned on her own.

 

 

While I love most of O’Keeffe’s  paintings, I’m less enamoured of her fashion, which the show presents as an element of her artwork.  In my view, it seems to have become more traditionally masculine–with chunky-looking  black suits ordered from a men’s clothier in Hong Kong– as she moved on in life.(Or, as women’s societal roles changed?) 

 

 

 

 

 

 

 

 

 

 

 

I’ve  seen quite a few O’Keeffe shows over the years..several in New York, and one in Glens Falls, NY, near Lake George– but this is the first I’ve seen that incorporates and integrates so many aspects of her life.

I would have liked to have been told a bit more about O’Keeffe’s childhood and family and about her relationship with Stieglitz, but then, there’s Wikipedia for that. All in all, I found the exhibit of an artist who worked well into her 90s enriching and inspirational.

 

Should also mention the wonderful docent and ceramic artist/jewelry maker who told me that the unlabelled photos were taken by O’Keefe and encouraged me and other visitors to share our comments and photos on Instagram.  Also, btw, the PEM  cafeteria serves the richest, thickest hot chocolate I’ve ever tasted.

Georgia O’Keefe, Art, Image, Style will be at the Peabody Essex Museum, Salem, MA, Dec. 1-April 1, 2018. 

–Anita Harris
Anita M. Harris is a writer, photographer and communications consultant  basedin Cambridge, MA. She is the author of Ithaca Diaries, Coming of Age in the 1960s, and Broken Patterns: Professional Women and the Quest for a New Feminine Identity.

New Cambridge Observer is a publication of the Harris Communications Group, a PR and content marketing firm based in Kendall Square. :

Wearables, robots, monitors, and IT systems for long-term care and  delivery systems. 

Part I Overview, Watson, Analytics
Part II digital devices, long term care.
Part III Apps, devices, roadblocks

At a recent health systems innovation organized the MIT/Sloan MIT  Initiative for Health Systems Innovation (HSI), experts from a variety of fields described current and envisioned methods for streamlining, personalizing and cutting the costs of health care in the US.  Among them were : wearables; robots; sophisticated monitors;  and digital methods to better coordinate communication and care.

 

Long Term care
On a panel covering digital innovation and long-term care, Thomas Grape, founder, chairman and CEO of Benchmark Senior Living,  described a variety of digital devices and methods used in his more than 60 facilities and elsewhere to improve care,  streamline operations and  cut costs amid a projected shortage of elder care workers.

Among digital innovations for patient care are:

• “Real time” monitoring and location systems to keep track of patients in dementia wards
• Wearables (such as vests or bracelets) with sensors that monitor movement to prevent falls
• Virtual and augmented reality devices such as “Wayback,” designed to enhance the experiences of individuals in early stages of mental decline—for example, by allowing them to “visit” faraway places or feel that they are attending historic events.
• Robots, such as”Jibo,” to keep patients company and entertain them. The robot, Jibo is “powered” by face and voice recognition. According to the Jibo Web site, the robot “remembers” people and builds “relationships” with everyone “he” meets.  Engineered by “character designers,” the robot has a “3-axis motor system” and “the moves” to match the personality of the human it is interacting with.
• Monitors that respond catastrophic events and proceed along“critical paths”: for example, by calling an ambulance and transferring a nursing home resident’s file even before a nursing home knows a patient has fallen and needs to go to the hospital.

Digital innovations for facilities and operations aimed, largely, at reducing staffing costs include:

• Monitors to measure light levels in hallways
• Exoskeletons,  worn by staff to cut the number of aides needed to lift and assist patients
• Robotic machines to help people in and out of chairs and toilets
• Automation of repetitive” back-office” business tasks.

 

Healthcare Delivery and Health Management

IT-Based Startups
On a panel showcasing three young companies, entrepreneurs described new methods for streamlining and coordinating healthcare delivery and management.

• Elliot Cohen, founder and chief technology officer of Pillpack, described his company’s “behind the scenes” effort to make managing and taking medication a “delightful” experience for patients. “Pillpack” uses information technology to coordinate physicians’ prescriptions and insurance companies in order to prepackage and send medication to patients exactly as it will be taken.
• Liz Boehm, research director of the Vocera Communications Experience Innovation Network explained that her company is focused on “unified clinical communications.” Vocera employs digital technology to align and manage workflow by connecting  patients, clinicians, and clinical systems.
• Health Reveal offers “a cloud-based digital health solution” to detect, monitor, and recommend prevention options for patients at risk for developing full-blown chronic disease, according to Christine Tsien Silvers, MD, the company’s chief medical officer. The system, paid for by insurers, includes not only purchasers, payers, providers and accountable care organizations but also patients, (who receive financial incentives for adherence to recommendations), pharmaceutical companies and device manufacturers, Silvers said.

In Part 3, I’ll describe promising mobile apps for behavioral health; personalized care and long-distance care as well as new state models to integrate community, health and social systems so as to better track and care for patients. I’ll also report on roadblocks to change.

LINKS TO
Part I Overview, Watson, Analytics
Part II digital devices, long term care.
Part III Apps, devices, roadblocks

 

Videotapes and photos of the conference, held November 29, 2017,  are available at http://mitsloan.mit.edu/alumni/events/2017-cambridge-health-conference/

–Anita M. Harris

Anita Harris is a writer and communications consultant focusing on health, science and technology.
New Cambridge Observer is a publication of the Harris Communications Group, a content and digital marketing firm based in Cambridge, MA.

Imagine this: a city homeless shelter serves breakfast and dinner, but not lunch. Hungry residents regularly go to the fire station next door, complain of chest pain, get taken by  ambulance to the hospital ER where they are evaluated, at high cost, given lunch, and then transported back to the homeless shelter in time for dinner.

Such was a scenario laid out recently at the MIT Sloan School as an example from an inefficient US social and health care system that cannot adequately keep track of patients, manage health of the poor, or control costs.

The scenario was described by Jason Helgerson, Medicaid Director for the New York State Health Department, at a day-long conference entitled “Health Systems Innovation.”  At the November 29 conference,  experts from industry, government, science, medicine and academe laid out some of US health care’s daunting problems, along with new visions and hoped-for solutions —many powered by digital innovation.

In introducing the sessions, which were organized by the MIT Sloan Initiative for Health Systems Innovation (HSI), moderator Jay Levine  pointed out that, today, there is more uncertainty regarding health care than at any time since the enactment of Medicare in 1965—a result of “overwhelming” political turbulence and concerns about health insurance and a tax plan that could upend the health industry and lead to huge, unsustainable losses in health delivery. Levine is retired principal of ECG Management Consultants, Inc.

 Retzef Levi,  an MIT/Sloan management professor whose department hosts HSI, outlined burgeoning health issues that accompany an aging US population. He emphasized the need to “sow seeds now”  for a “visionary, futuristic system”  to prevent disease  and know who is at risk in order to reduce future illness.

Such a system would  integrate local, state, and national systems, medical  and behavioral disciplines, primary,  specialty and community care, Retsef said.  Providers would be paid for performance rather than tasks undertaken. There would be a workforce sufficient to handle the nation’s long term care needs, personalize diagnosis and treatment. The system would make full use of  digital health innovations such as big data, analytics, sophisticated devices and mobile apps without losing the best aspects of human care.

After Levi’s remarks, Levine asked, “ in light of huge current losses in the system, where does the money come from to fix it?”

Panelists at the day long meeting never fully answered that question, but they did lay out a variety of promising digital approaches that could lead toward transformation, as well as roadblocks to change.

Analytics, machine learning and artificial intelligence
In a panel on “Machine Learning in surgery and cancer”, MIT PhD Candidates Jack Dunn and Daisy Zhou described analytic tools, based largely on longitudinal patient records,  that they are developing  to predict how long an individual surgical patient is likely to live, with what quality of life, if certain decisions are made.  Such tools, which evaluate “nuanced “ signals and  make use of “decision trees,” are aimed at helping doctors decide on treatment plans. Under current treatment guidelines, Zhou said, many doctors tend to “overestimate” prognoses, which can diminish patients’ quality of life and increase medical costs.

Dusty Mojumdar, PhD, IBM vice president and chief marketing officer for an IBM artificial intelligence (AI) system that reads, learns, understands and interacts with humans. Named “Watson,” after IBM’s first president, Thomas Watson, the system is now used, in health care, to: combat a major shortage of radiologists; predict whether nodules on individuals’ lungs will become malignant; develop new targets for ALS drugs, predict hypoglycemic events for diabetics; rank treatment plans and options for seven cancers, and match patients to clinical trials.

Artificial intelligence is also  being used to evaluate what one speaker termed an “explosion “of health data—which is reported in some 7000 new health care publications per day, and which doubles every 73 days, according to Mojumdar.  Several massive health systems are employing  artificial intelligence to co-ordinate electronic medical records—using “text analysis” and “pattern matching” to “catalog” patients with similar health conditions in order to evaluate  and predict outcomes of particular treatments.

In September, IBM made a 10-year, $240 million investment to create the MIT–IBM Watson AI Lab to  carry out fundamental AI research aimed at propelling scientific breakthroughs that unlock the potential of AI.

In Part II, I’ll share panelists’ information about a variety of digital devices and methods already in use to help streamline and personalize long-term care and health care delivery.

 

LINKS TO:
Part I Overview, Watson, analytics
Part II digital devices, long term care.
Part III Apps, devices, roadblocks

Videotapes and photos of the conference, held November 29, 2017,  are available at http://mitsloan.mit.edu/alumni/events/2017-cambridge-health-conference/

–Anita M. Harris
Anita Harris is a writer and communications consultant specializing in health, science and technology.

New Cambridge Observer is a publication of the Harris Communications Group, a content, PR and digital marketing firm based in Cambridge, MA.

 

 

Having made calls and canvassed for Hillary Clinton over the weekend (and joked about her seeming a bit stiff –like cardboard–in the photo to the left),  I’m saddened, confused and a bit shocked by her loss to Donald Trump. I’ll be writing more about this in days to come, but for now, thought I’d share her concession speech, which I received in an email from her campaign, so that you could read it in its entirety. I found it eloquent and inspirational.

–Anita M. Harris

 

Thank you.

Last night, I congratulated Donald Trump and offered to work with him on behalf of our country. I hope that he will be a successful president for all Americans.

This is not the outcome we wanted or we worked so hard for, and I’m sorry we did not win this election for the values we share and the vision we hold for our country.

But I feel pride and gratitude for this wonderful campaign that we built together –- this vast, diverse, creative, unruly, energized campaign. You represent the best of America, and being your candidate has been one of the greatest honors of my life.

I know how disappointed you feel, because I feel it too. And so do tens of millions of Americans who invested their hopes and dreams in this effort. This is painful, and it will be for a long time. But I want you to remember this: Our campaign was never about one person or even one election. It was about the country we love — and about building an America that’s hopeful, inclusive, and big-hearted.

We have seen that our nation is more deeply divided than we thought. But I still believe in America –- and I always will. And if you do, too, then we must accept this result -– and then look to the future.

Donald Trump is going to be our president. We owe him an open mind and the chance to lead.

Our constitutional democracy enshrines the peaceful transfer of power, and we don’t just respect that, we cherish it. It also enshrines other things –- the rule of law, the principle that we’re all equal in rights and dignity, and the freedom of worship and expression. We respect and cherish these things too — and we must defend them.

And let me add: Our constitutional democracy demands our participation, not just every four years, but all the time. So let’s do all we can to keep advancing the causes and values we all hold dear: making our economy work for everyone, not just those at the top; protecting our country and protecting our planet; and breaking down all the barriers that hold anyone back from achieving their dreams.

We’ve spent a year and a half bringing together millions of people from every corner of our country to say with one voice that we believe that the American Dream is big enough for everyone — for people of all races and religions, for men and women, for immigrants, for LGBT people, and people with disabilities.

Our responsibility as citizens is to keep doing our part to build that better, stronger, fairer America we seek. And I know you will.

I am so grateful to stand with all of you.

I want to thank Tim Kaine and Anne Holton for being our partners on this journey. It gives me great hope and comfort to know that Tim will remain on the front-lines of our democracy, representing Virginia in the Senate.

To Barack and Michelle Obama: Our country owes you an enormous debt of gratitude for your graceful, determined leadership, and so do I.

To Bill, Chelsea, Marc, Charlotte, Aidan, our brothers, and our entire family, my love for you means more than I can ever express.

You crisscrossed this country on my behalf and lifted me up when I needed it most –- even four-month old Aidan traveling with his mom.

I will always be grateful to the creative, talented, dedicated men and women at our headquarters in Brooklyn and across our country who poured their hearts into this campaign. For you veterans, this was a campaign after a campaign — for some of you, this was your first campaign ever. I want each of you to know that you were the best campaign anyone has had.

To all the volunteers, community leaders, activists, and union organizers who knocked on doors, talked to neighbors, posted on Facebook – even in secret or in private: Thank you.

To everyone who sent in contributions as small as $5 and kept us going, thank you.

And to all the young people in particular, I want you to hear this. I’ve spent my entire adult life fighting for what I believe in. I’ve had successes and I’ve had setbacks -– sometimes really painful ones. Many of you are at the beginning of your careers. You will have successes and setbacks, too.

This loss hurts. But please, please never stop believing that fighting for what’s right is worth it. It’s always worth it. And we need you keep up these fights now and for the rest of your lives.

To all the women, and especially the young women, who put their faith in this campaign and in me, I want you to know that nothing has made me prouder than to be your champion.

I know that we still have not shattered that highest glass ceiling. But some day someone will -– hopefully sooner than we might think right now.

And to all the little girls watching right now, never doubt that you are valuable and powerful and deserving of every chance and opportunity in the world.

Finally, I am grateful to our country for all it has given me.

I count my blessings every day that I am an American. And I still believe, as deeply as I ever have, that if we stand together and work together, with respect for our differences, strength in our convictions, and love for this nation -– our best days are still ahead of us.

You know I believe we are stronger together and will go forward together. And you should never be sorry that you fought for that.

Scripture tells us: “Let us not grow weary in doing good, for in due season, we shall reap, if we do not lose heart.”

My friends, let us have faith in each other. Let us not grow weary. Let us not lose heart. For there are more seasons to come and there is more work to do.

I am incredibly honored and grateful to have had this chance to represent all of you in this consequential election. May God bless you and god bless the United States of America.

Hillary

 

Anita M. Harris, a writer and communications consultant, is the author of Broken Patterns, Professional Women and the Quest for a New Feminine Identity. Broken Patterns is about women of the baby-boom generation in relation to their mothers and grandmothers. It presents a spiral theory of change, which, Harris believes, goes far in explaining the current election results.

New Cambridge Observer is a publication of the Harris Communications Group, based in Cambridge, MA.