Much enjoyed last week’s opening of the Koch Institute’s 2017 Image Awards Exhibition. The exhibit, dubbed “with/in/sight”  includes 10 scientific images chosen as best-in-class from among some 120 entries from MIT life scientists and their collaborators across the country–and one from Ireland.

The display, in the public galleries at the Koch Institute for Integrative Cancer Research, is the Koch’s seventh in as many years. Its goal is to celebrate “the diversity of biomedical research at MIT and offers insight into the important role that science and engineering play in our complex and ever-changing world,” according to a Koch brochure.

The images are printed on t-shirt material stretched across frames back lit with LEDs. They are striking artwork in themselves– and showcase some of the most exciting work under way in the cancer research arena.

“Making Waves” conveys research on non-invasive sound waves that carry genetic material through protective layers of skin, transferring genes to cells whose genetic clocks have been turned back by the nucleic acids they have received– in order to reverse skin-aging. Credits go to Carl Schoellhammer, Denitsa Milanova, Hamberto Trevino, Cody Cleveland, Jeffrey Wyckoff, Anna Mandinova, Giovanni Traverso, Robert Langer, and George Church.

 

 

 

 

At the Whitehead Institute, Samuel LoCascio, Kutay Deniz Atabay and Peter Reddien are studying planarian flatworms to learn more about how they regerate. Each color in their image represents a different layer of neurons in the flatworm’s head.

 

Dahlia Perez and Jacqueline A. Lees are studying zebrafish to provide insight into melanoma. This image shows the organization of zebrafish cells in their normal state. Next, biologists will mutate a single gene known to initiate a certain melanoma in order to determine its “downstream” effects.

 

Steffen RIckelt and Richard Hynes of the Koch Institute are studying not the clusters of brownish colon cancer metasteses shown in the image, screen, but, rather, the “seeming neutral” tissue matrix around them. The goal is determine how the matrix impacts the progression of tumor cells navigating a complex network of cells and proteins.

Langliang Hao, Srivatsan Raghavan, Emilia Pulver, Jeffrey Wyckoff and Sangeeta Bhatia of the Koch Institute are using  biocompatible nanoparticles (yellow) to target and penetrate clusters of cancer cells (pink) with the goal of delivering treatment.

 

 

Colin Edington, Iris Lee and Linda Griffith of MIT are involved in the Griffith lab’s “Human on a Chip,” project, in which many different”mini organs”, developed from stem cells in matrix, are linked together in a bioreactor platform. The researchers are studying interactions of multiple organs and the cross between them in order to develop new disease treatments. Shown here are neurons (green) and astrocytes (red).

 

 

Selim Olcum, Nathan Cermak and Scott Manalis are using microfluidics to measure the response of cell masses to drugs. Their image shows fluid filled channels (bottom) connected to tiny mass sensors shaped like hollow diving boards (top); the sensors’ whose  vibrations precisely reveal the mass of individual cells passing through them. As treated cells flow across the array of sensors, each cell is weighed multiple times, thereby revealing how quickly the mass of individual cells is changing. Researchers are beginning to use this method to predict optimal treatment strategies for individual patients.

 

My favorite image does not show cells, nor was it submitted by an MIT lab. Rather, it visualizes twitter conversations about breast cancer carried out by a network of connected cancer patients and their loved ones, patient advocates, health care professionals, and researchers. The image, by Erie Clarke, Richard Arnett and Jane Burns of the Royal College of Surgeons in Ireland,  represents 92, 915 tweets posted over an eight-week period. It is from the Wellcome Images collection.

 

Other images not included here display pathways taken by metatastic lung cancer cells over time and  ovarian cancer cells as they break through the abdominal wall.

I’m the first to admit that these photos do not do justice to the real images–nor do they adequately convey the amazing convergent technologies –including imaging–used to carry out the research.

The gallery,  at street level in the Koch Institute, 500 Main Street, in Cambridge, is open to the public at no charge from 8-6 Monday-Thursday, and until 4 pm on Friday. The images are also visible from the sidewalk, outside.

Through March 2018.

 

Anita Harris is a writer, photographer and communications consultant based in Cambridge, MA.
New Cambridge Observer is a publication of the Harris Communications Group, an award-winning PR and market development firm located in Kendall Square, Cambridge.

On my way to a meeting at MIT, I happened to spot some stunning photos through the window of what turned out to be the Philip Alden Russell Gallery of the  David H. Koch Institute for Integrative Cancer Research. I contacted the Institute-which opened in March–and learned that the photos are featured in a gallery designed to connect the community with the Koch’s work.  I happily accepted Curator  Alex Fiorentino’s offer  to show me around.

On my tour,  Fiorentino  explained that the galleries are designed so that visitors can explore current cancer research projects, examine striking biomedical images, hear personal reflections on cancer and cancer research, and learn about the historical, geographic and scientific contects out of which the Institute emerged. The photos, he said, were taken under microscopes by Koch research scientists and collaborators–chosen through a contest,  then blown up, printed on fabric, adhered to stretchers over light sources,  Each has a scientific story to tell. The photo just below for example, is one I took of an EI-fluorescence micrograph by  Christian Kastrup of the Anderson and Langer Labs at the Koch. It shows a new  technique for delivering treatments to a blood vessel (seen in blue) using nanoparticles and microparticles. According to a Koch publication,  the original image was dark, with nanoparticles, microparticles and the blood vessel each stained a different color. But, in this version–to which my photo does not do justice— the original colors are inverted.

Another beauty is Kara Cerveny’s confocal micrograph–“Sunrise in the Eye: the Making of a Retina.”  Taken by the Koch collaborator at the Steve Wilson Group at University College, London, it is part of Cerveny’s investigations into how stem cells in the zebrafish eye differentiate to become more specialized cells. Her goal is to gain insight into how the normal development process goes awry in cancer and other diseases. There are ten award-winning photos displayed– all viewable any time through the Koch windows or inside during gallery hours–9-5 on weekdays.

Other gallery highlights include exhibits on five new technologies to combat cancer being developed at the Koch;  a “video box” providing 16 presentations by cancer patients, their families and scientists;  wallpaper showing cellular processes, a mosaic floor composed of thousands of tiles laid out to form a map of the Kendall Square area; and  timelines showing the parallel histories of science and engineering at MIT. The timelines converge in the present, with  the Koch’s cross-disciplinary approach to cancer.  And–just inside the lobby there’s an attractive cafe.

As a journalist, I’d be remiss not to mention that David Koch, an MIT alum–has been the subject of some controversy. According to a 2010 article in  the New Yorker, as a  cofounder  of  Koch Industries,   the nation’s second largest privately-held corporation, he and his brother Charles are major funders of conservative/libertarian causes.  But, Wikipedia reports,  gifts of  $600m  for scientific research and the arts surpass David Koch’s  political donations.

While ordinarily I wouldn’t think that cancer research would be much of a draw, the gallery,  named for  financeer Philip Alden Russell– a mentor of funder Charles B Johnson and his wife Anne Johnson– is well worth a visit. Or several.

–Anita M. Harris

Koch Institute Public Galleries 500 Main St. Cambridge, MA Open to the public 9-5 weekdays. Admission Free.

New Cambridge Observer is a publication of the Harris Communications Group, an award-winning public relations and marketing communications firm located in Cambridge, MA.