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Interview: MIT biotech pioneer Bob Langer on how to avoid the “valley of death”

I recently interviewed Bob Langer–MIT biotech guru extraordinaire–on behalf of the EBD Group, which holds international partnering conferences for the life sciences six times a year.  Here’s the opening…and a link to the rest, on the EBD Site. The piece will also  appear in xconomy shortly. Full disclosure…Bob is a personal friend, former classmate, and a member of the Harris Communications Group advisory board…so this should be considered a sponsored post.

–Anita M. Harris

 

When Bob Langer joined the MIT faculty in 1977 he had a rocky start. Trained as a chemical engineer and working on drug delivery systems, many of his ideas went against conventional wisdom. “I had people write the most insulting things about my knowledge of biology and medicine. Many thought my ideas were crazy. A number of professors wanted me to leave and my first nine grant proposals were turned down.”

Eventually, after numerous academic scientists and companies repeated and used his work Langer was able to get grant funding from the NIH. He also turned to companies for research funding—in return for licensing his patents—which, at that time, also went against the conventional grain.

Today, Langer is one of 13 Institute Professors (being an Institute Professor is MIT’s highest honor) at Massachusetts Institute of Technology. With more than 1,400 articles to his credit, he is the ninth most cited individual in history, according to Google scholar. (Sigmund Freud is first). His 1,300 patents, licensed or sublicensed to more than 350 companies in pharmaceutical, chemical, biotechnology and medical device fields, have led to more than 100 products currently in use or in clinical trials. He has received more than 220 major professional awards including the Queen Elizabeth Prize for Engineering, Priestly Medal, National Medal of Science, National Medal of Technology and Innovation, the Charles Stark Draper Prize (considered the equivalent of the Nobel Prize for engineers), and the Lemelson-MIT prize for being “one of history’s most prolific inventors in medicine.” In June 2018, he was named a US international envoy for science by the US State Department.

Despite his success, Langer remains well aware of his early setbacks, and, as a scientific advisor to some 200 companies over the past 40 years, is highly cognizant of what can go wrong.

“You can have bad animal results, failed trials, or patent problems. I’ve seen partners pull out, companies take bad loans, and the FDA create delays. Stumbling blocks can arise anywhere along the way,” he says.

One of the most difficult problems can occur early on “when a researcher has good findings but is not far enough along for investors or companies to want to spend a lot of money.” In that situation, known as “the valley of death,” Langer says, “the question is how to get enough data so that will change.”

More: 

 

Anita M. Harris is a writer and communications consultant based in Cambridge, MA.

New Cambridge Observer is a publication of the Harris Communications Group, also in Cambridge.




Ithaca Diaries Intvu to be featured on NPR “Here and Now” Monday, May 25

Book Cover 6x9 9-13-14 - CopyExcited to have been interviewed about Ithaca Diaries by radio personality  extraordinare Lisa Mullins.  A segment is slated to air nationally on NPR’s “Here and Now,”  on Memorial Day, May 25, 2015.  The  program airs live on WGBH Boston from 12 p.m. to 2 p.m. Both in Boston and elsewhere you can  choose a live stream from WBUR or Click here for a searchable list of public radio stations that broadcast Here & Now.

 

According to the Here and Now WHere and Now with Robin Young and Jeremy Hobsonebsite, you can also:

Hear individual stories: Audio for stories in the first hour of Here & Now is typically posted by 2:30 p.m. EST. Audio for stories in the second hour is typically posted by 3:30 p.m. EST. You can listen to past shows by browsing or searching the archives.

Hear the whole show: You can stream each hour of Here & Now using the WBUR mobile app. A podcast of each hour is also available in the iTunes store, within hours of its air time (better time estimates coming soon). For more ways to download the podcast (not using iTunes), go here.

About Here and Now:
Here and Now
is a live production of NPR and WBUR Boston, in collaboration with public radio stations across the country.  According to its Website, the program reflects the fluid world of news as it’s happening in the middle of the day, with timely, smart and in-depth news, interviews and conversation.

Co-hosted by award-winning journalists Robin Young and Jeremy Hobson, the show’s daily lineup includes interviews with NPR reporters, editors and bloggers, as well as leading newsmakers, innovators and artists from across the U.S. and around the globe.

Here & Now began at WBUR in 1997, and expanded to two hours in partnership with NPR in 2013. Today, the show reaches an estimated 3.6 million weekly listeners on over 383 stations across the country.

Ithaca Diaries posterAbout Ithaca Diaries
Ithaca Diaries  is a coming of age memoir set at Cornell University in the tumultuous 1960s. The story is told in first person from the point of view of a smart, sassy, funny, scared, sophisticated yet naïve college student who can laugh at herself while she and the world around her are having a nervous breakdown. Based on Harris’ own journals and letters, interviews and other primary and secondary accounts of the time, Ithaca Diaries describes collegiate life as protests, politics, and violence increasingly engulf the student, her campus, and her nation. Her irreverent observations serve as a prism for understanding what it was like to live through those tumultuous  times.While often laugh-out-loud funny, they provide meaningful insight into the process of political and social change we are continuing to experience, today.

Ithaca DIaries is available from Amazon, Kindle and the Cornell Campus Store.

Anita M. Harris is an award-winning writer, blogger, and communications consultant based in Cambridge, MA. A new edition of her  first book, Broken Patterns, Professional Women and the Quest for a New Feminine Identity, was published in 2014. 

New Cambridge Observer is a publication of the Harris Communications Group, an award-winning PR and marketing firm based in Cambridge, MA.

 

 

 




Paris/Cambridge Ariana Pharma Joins Worldwide Cancer Network WIN

Butterly-from Ariana Pharma Website

Butterly-from Ariana Pharma Website

Our Cambridge Innovation Center colleague Ariana Pharma reports that it has joined the WIN consortium as an official technology partner. Congrats! Here’s the release. 

Paris, France, and Cambridge, Massachusetts USA, 29 October 2014 – Ariana Pharma, developer of innovative clinical data analysis and diagnostic solutions for the healthcare sector, today announced it has joined the WIN Consortium as an official technology partner. The Consortium (Worldwide Innovative Networking in personalized cancer medicine) is a global collaboration of 40 leading organizations whose aim is to develop more effective cancer diagnostics and therapeutics, shorten clinical trial timelines and reduce the overall cost of cancer care.

The new WIN/Ariana partnership is expected to accelerate the translation of personalized medicine discoveries into widely available new standards of care for all cancer patients, leading to significantly improved clinical outcomes and a higher quality of life for cancer patients.

As a technology partner of the WIN Consortium, Ariana will have early access to the latest research, key opinion leaders, leading academic groups and personalized medicine clinical trials. Ariana uses OncoKEM®, a proprietary clinical decision support platform for personalized medicine, to transform big data into better therapeutic decisions for cancer patients.

Ariana Pharma Founder and Chief Executive Officer Dr. Mohammad Afshar said: “We are delighted to be an official technology partner of the WIN Consortium where we can continue to leverage our expertise in patient stratification, multi-marker diagnostic optimization and data mining to transform complex clinical data into actionable information. Our expanded access to the leading global stakeholders in personalized medicine will allow us to test new hypotheses, to enhance interaction to yield valuable feedback and thus accelerate the development process and commercialisation of these critical new services for the global cancer community.”

“We are delighted to welcome Ariana Pharma in our consortium. Ariana Pharma provides outstanding computational skills enabling the translation of academic projects into commercial tools to support the therapeutic decision for cancer patients,” said Dr. John Mendelsohn, Chairman of the WIN Consortium.

WIN is recognized for pioneering the evolution of next-generation clinical trials, which test personalized treatment selection strategies rather than single drugs. These strategies are driven by algorithms that match targeted therapies or combination therapies to individual tumor biological profiles based on diagnostic analysis of genomic data and other information.

In 2013 the WIN Consortium chose Ariana Pharma to develop and globally commercialize ground-breaking decision support software in WIN’s WINTHER trial, the first state of the art clinical trial in personalized cancer medicine to help clinicians choose the best therapies for cancer patients. Ariana retains exclusive global rights to commercialize software and algorithms validated by the WINTHER clinical trial through Ariana’s OncoKEM® platform.

About Ariana Pharma

Ariana Pharma develops innovative clinical data analysis and diagnostic testing solutions to help the healthcare sector better adapt patient treatments to individual biological characteristics. Ariana Pharma’s KEM® technology enables personalization of therapies, improves the efficacy and safety of patient treatment, reduces risks and drug development costs, and accelerates time to market. KEM® is the only FDA tested technology that systematically explores combinations of biomarkers, producing more effective biomarker signatures for personalized medicine. Founded in 2003 as a spin-off of the Institut Pasteur, Paris, France, the company opened a subsidiary in the United States in 2012.For more information, please visit www.arianapharma.com

About the WIN Consortium

Founded in 2010, WIN is an initiative from the Institut Gustave Roussy (France) and University of Texas MD Anderson cancer center (USA). WIN is unique structurally in that it brings together organizations from academia, business and not-for-profits to focus on translating the latest advances in personalized cancer medicine into the standard of care. WIN is built on the recognition that all stakeholders in personalized cancer therapy must collaborate and share information, in order to effectively bring the latest innovations in personalized cancer care to the patient. WIN is a non-profit organization formed by 40 renowned members: Academic cancer centres (25 centres in 16 countries), companies (Blue Cross Blue Shield, Agilent Technologies, GE Healthcare, Oracle Health Services, Foundation Medicine, Millennium Takeda, AstraZeneca and Pfizer), non-profit organizations such as EORTC, Fondation ARC and Sage Bionetworks. WIN organizes an annual symposium in Paris dedicated to personalized medicine. For further information, please visit www.winconsortium.org  and www.winsymposium.org.

–Anita M Harris
New Cambridge Observer is a publication of the Harris Communications Group, an award-winning pr and marketing firm based in Cambridge, MA. {Ariana is not our client]. AMH.




BTW Mag for sustainable homes kickstarter needs $3K, with 3 days to go

BTW: The Magazine of Beautiful, Healthy & Sustainable Homes's video posterWith three days to go, the kickstarter campaign for BTW (Behind the Walls)  –a multi-platform media company devoted to beautiful, healthy, energy efficient and sustainable home, .is 85% funded.  Led by our friend and Cambridge Innovation Center colleague Harold Simansky, BTW needs $3K to get to $25K tor will take in nothing at all. I hope you’ll support the project. Here’s a link to the kickstarter site:

Harold writes:

Environmentally sound, healthy homes can be as stylish as they are sustainable; as beautifully designed as they are responsible; as glam as they are green… and a lot less expensive than you might think.

Now that eco-awareness is (finally and thankfully) skyrocketing, the country has exploded with new ideas for the home—everything from innovative, energy-saving technologies and home automation systems to products, decors, and furnishings that are toxin-free, sustainable and beautiful. Now you can live a green life at home without having to choose between what’s eco-friendly and what’s style-friendly, what’s efficient and what’s expensive.

BTW is here to keep homeowners on the cutting edge, building a community that shares our vision of healthy, energy-efficient and sustainable building and renovation practices, met with beautiful design. We’re also here to educate the community about service providers and funding—in the form of thousands of rebates and incentive programs—to make that possibility a reality. We want to make it clear that living a healthy, energy-efficient, and happy green lifestyle is within reach… and it all begins in the home.

What We Do

We’re creating a vibrant community of forward-thinking homeowners with BTW: Behind the Walls, a multi-platform media company that combines a magazine (both print and online), a website, social media, videos, blog posts, creative events, and—soon to come—podcasts and ecommerce, to help consumers envision and create a new kind of home and lifestyle.

Our goal is to help all homeowners understand, as they undertake some 20 million home improvement projects every year, how to do it more efficiently, more stylishly, greener, and healthier, using the best products, services and funding.

https://www.kickstarter.com/projects/959029715/btw-the-magazine-of-beautiful-healthy-and-sustaina?ref=home_featured

–Anita M. Harris
Anita Harris is a writer and communications consultant in Cambridge, MA.
New Cambridge Observer is a publication of the Harris Communications Group, an award-winning PR and digital marketing firm based at the Cambridge Innovation Center, in Cambridge, MA.




Millennials Support Ithaca Diaries Kickstarter Campaign

Book Cover 6x9 9-13-14 - CopyHi! I’m thrilled with the outpouring of support for Ithaca Diaries– including that of current students and recent grads.

Alex Tomasi, a 2014 Boston University communications grad (and race car driver!)  has offered a beautiful, whimsical poster as a new reward–(shown below the cover photo).

 

 

anita-poster-legalsmallYou can meet Alex and other 20-something supporters– Erin Euler, Eric Morris (Cornell 2012),  Grant Randall  and Ben Whiting  via their brief You Tube videos….and I hope at the launch party in January.

Any and all contributions welcome–including $1 and $5.  Every little bit helps–and also raises projects in the kickstarter rankings and attracts more views. It would also be great if you’d’ share this email and the kickstarter link on social media.

Here’s the kickstarter link:
https://www.kickstarter.com/projects/1639099206/ithaca-diaries-coming-of-age-in-the-1960s.

It does look like we’ll reach the goal soon…which means that Ithaca  Diaries will be available for holiday gift giving. Additional $$ will allow a Kirkus review to let bookstores and libraries know it’s available–and still more will go toward an interactive Web site.

Many many thanks,
Anita M. Harris

Anita M. Harris is a writer and communications consultant in Cambridge, MA.
New Cambridge Observer is a publication of the Harris Communications Group, an award-winning public relations and marketing firm, based in Kendall Square, Cambridge.




Anita M. Harris launches kickstarter for Ithaca Diaries, Coming of Age in the 1960s

Ithaca Diaries cover

Ithaca Diaries Cover

I’m ecstatic to have finally launched a kickstarter campaign to bring Ithaca Diaries to life! And that the campaign is now already featured as a staff pick! Here’s the link…https://www.kickstarter.com/projects/1639099206/ithaca-diaries-coming-of-age-in-the-1960s?ref=category_recommended .

In case you can’t quite see the writing on the cover, left:

Ithaca Diaries is  coming of age memoir set at Cornell University in the tumultuous 1960s. The story is told in first person from the point of view of a smart, sassy, funny, scared, sophisticated yet naïve college student (moi) who can laugh at herself while she and the world around her are having a nervous breakdown. Based on diaries, letters, interviews and other primary and secondary accounts of the time, Ithaca Diariesdescribes collegiate life as protests, politics, and violence increasingly engulf the student, the campus, and the nation.  I hope my irreverent observations will serve as a prism for understanding what it was like to live through those precarious times. While often laugh-out-loud funny, I believe they provide meaningful insight into the process of political and social change from which we are reaping the benefits, today.

It would be great if you’d share this blog with anyone who might be interested….and contribute to the kickstarter campaign!
Many thanks, Anita

New Cambridge Observer is a publication of the Harris Communications Group, an award-winning PR and Marketing firm based in Cambridge, MA.
Anita Harris is it’s Managing Director. She is also the author of Broken Patterns, Professional Women and the Quest for a New Feminine Identity. 

 

 




Cambridge Art Association Fall Salon and 70th Season now open

FALL_SALON_WEBT1_Postcard-Fall-Salhe Cambridge Art Association’s 70TH exhibition year, opened Friday, September 12, with the 70th Fall Salon, CAA announced in a press release, yesterday.

The salon  runs through September 26, 2014, in both the Kathryn Schultz Gallery (25 R Lowell St)   and
University Place Galleries (125 Mt. Auburn St). Awards were presented on Friday, September 12.

CAA Event Calendar

The opening  honored the memory of longtime member and supporter Mary Schein, whose husband, Edgar Schein, has provided longtime sponsorship and support of the Fall Salon. The 70th Fall
Salon features artwork in a range of media from 144 Cambridge Art Association Artist Members.

Of the prizewinners, who were each awarded $250, Edgar Shein writes:
Jim Kociuba (Cambridge, MA) – November Rain, oil on canvas
This painting captures the style, color and content of what I always thought Mary appreciated—gentle
colors, a simple natural beautiful theme of the receding stream, and a softness of style we associated with some of the paintings of Vuillard and Redon both of whom Mary loved. I have to admit after looking them up on Google that much of their work was anything but gentle and soft, but when they did achieve it, it had a special quality that always attracted us greatly.

Susan Burgess (Cambridge, MA) – Maine Retreat, oil on canvas
This painting is a wonderful reminder of the summers Mary and I spent in Maine. We divided our time
between Bethel, where I worked, and the ocean that she loved, having grown up in Carmel, California. The two coasts are totally different, with the young California coast plunging steeply into the sea, while the geologically much older Maine coast gently eases into the ocean as this painting so elegantly shows. Our favorite places were Boothbay Harbor and Rockland where we spent several summers at the grand old Samoset Hotel. The peaceful and calming and eternal vista of this painting could be seen over and over again all along the coast.

Upcoming exhibits: 

  • Time Travelers – a small group show with work by Stephen Martin, Conny Goelz-Schmitt, and Lorraine Sullivan October 2–30, 2014. Opening reception, Thursday, October 2, 6-8pm at Kathryn Schultz Gallery
  • 70th Members Prize Show, juried by Al Miner (Assistant Curator of Contemporary Art, Museum of Fine Arts, Boston)October 10 – November 15, 2014. Opening reception: Friday, October 10, 6-8pm at University Place Gallery
  • Motion Envisioned – a small group show with work by Bea Grayson, Bob Hesse, and Ruth LieberherrNovember 4-29, 2014. Opening reception, Saturday, November 15, 1-3pm at Kathryn Schultz Gallery
  • PLATINUM – Northeast Open Show, juried by Alise Upitis (Assistant Curator, MIT List Visual Art Center)December 4, 2014 – January 16, 2015. Opening reception Friday, December 5, 6-8pm at the Kathryn Schultz Gallery and University Place Gallery.

–Anita M. Harris
New Cambridge Observer is a publication of the Harris Communications Group, an award-winning PR and marketing firm based in Kendall Square, Cambridge, MA. 

Anita Harris is a communications consultant and the author of Broken Patterns, Professional Women and the Quest for a New Femninine Identity (2014) and the forthcoming Ithaca Diaries, Coming of Age in the 1960s. (Spring, 2015).

 

 




New “Map of the Web” puts Boston area arts in geographic perspective

home When I checked out Yuvee, Inc.’s newly launched “map of the Web” for visual arts in the greater Boston area, I was pleased to find links to the various museums and galleries laid out on a single page that showed museums’ geographic relationship to one another–and leading to brief summaries of each museum’s collection, its Twitter, Pinterest, and other social sites, as well as its address and phone number. Public Art Tour

 

But I was more than pleased–actually, I was  amazed to find a section devoted to public art –including small galleries and installations– some of which are in quite out-of the way places. For example, one link, to the City of Cambridge’s public art tour,   took me to a mesmorizing video installation I’d first discovered after attending a Yoga class at the youth center  on Huron Avenue.

 

The video, by The Cantabridgians”, by Michael Oatman, includes 23 1-minute portraits of Cambridge Residents posed with objects in locations of their choice, designed to provide a sense of them in their particular neighborhoods.

 

Other links from  Web Hub’s map of the “public”  visual arts go to the City of Boston Public Art sites and the Rose Kennedy Greenway.

 

Boston Art Map - Map Panel View - Screen Capture - 8.27.2014 (1)The Boston Art Map, accessible at maps.webhub.mobi/boston-art, is one of the first sites brought to “life” by newly launched “Yuvee, Inc.,” under the auspices of “WebHub” and “A Social Atlas of the Web.”   According to Yuvee founder Tim Higginson, WebHub is focused on enabling the next generation of Web experience for the “cross device”‘ lifestyle in which individuals use smartphones to access the web.

 

“An atlas is a collection of geographic maps, which help people find their way from A to B, learn and explore what is in an area and see connections between places, Higginson explains.  “Maps” of the Web do the same thing for people who are using the Internet. They give people an Instant, organized way to find and explore a whole of resources and the ability to switch easily among maps on different topics. At http://WebHub. mobi, “anyone can make a map of the Web on any topic,  and share the map with others.

 

According to Higginson, the map concept is ” a vast improvement” over traditional search engines, which deliver long, linear lists with items separated from the others, and require individual searches and sifting through pages of results. Such lists do not convey interrelationships and structure among items. Other resources, such as Pinterest, Tumblr, Facebook and Youtube tend to focus on single types of information. In contrast, he explains , “maps” of the Web can pull all these relevant items together in a structure, organized and annotated way, in a single URL that is always available from anyone’s smartphone, tablet, laptop, pc or other Web-enabled device.

 

The maps are independent of browser and OS, do not require downloads, syncing, re-doing searches, typing urls, or even knowing a  know a URL on a topic covered by a map to get an in-depth experience of the Web on that topic. What is more, Higginson says, “WebHub is free and respects its users’ privacy. “We hope this Boston Art ‘map of the Web’ gives people a richer, faster, easier way to learn about and enjoy all the incredible things that are going on in the visual arts in and around Boston..and that people enjoy all the other maps available at www..webhub.mobi.”

I note that it’s possible to advertise on WebHub, which, Higginson says, is its business model.

 

–Anita M. Harris New Cambridge Observer is a publication of the Harris Communications Group, an award-winning public relations and marketing firm based in Cambridge, MA.