SHANAHAN NAMED VP OF BUSINESS DEVELOPMENT

—One of the newest international companies to expand into Cambridge is Ariana (R)  Pharma–a 2003 spin-out of the Pasteur Institute in Paris.  Its  subsidiary, Ariana Data Intelligence, Inc., located in the Cambridge Innovation Center at 1 Broadway,  will provide novel non-statistical clinical data analysis technology to pharma and the FDA,  Ariana announced today.

The technology,  “Knowledge Extraction and Management Technology (KEM)” is aimed at reducing cost, bias, and risk in clinical trials.

“The US pharma and biotech markets tend  to be early technology adopters and are searching for better data analytics tools to advance personalized medicine using all the new biomarker, genomic, proteomic and metabolomic data now being generated,” said  Dr. Mohammad Afshar, Ariana’s President and CEO.

KEM   “is the only FDA-tested technology that  can simultaneously analyze all these variables and pull out patient responder sub-groups, optimize biomarker signatures and remove bias from clinical trials,” Afshar said.

A “unique” association rules-based (non-statistical) analytical technology, KEM  finds patient responder sub-populations and biomarker signatures that statistical methods are unable to detect, according to Afshar.  KEM thus optimizes clinical trial inclusion/exclusion criteria, thereby lowering the number of patients needed to reach clinical endpoints and saving sponsors both time and cash, and reducing clinical drug development risk.

In conjunction with the opening, Ariana has appointed James M. Shanahan as Vice President  of Business Development.  Shanahan was previously a co-founder and is currently a  board member of SynDevRx, Inc., an oncology-focused biotech company. He was also a co-founder and VP Corporate Development of JAM Technologies, Inc.

Ariana offers something “special and desperately needed “by the pharmaceutical industry, Shanahan said.   “Companies spend tens of millions generating data.  Now, it’s all about making sense of that data.  KEM identifies useful, complex biological relationships that statistics routinely miss.”

More information is available at  http://www.arianapharma.com/  .

–Anita M. Harris

Earlier this week,  I had the privilege of attending the tenth annual “BIO-IT World Conference and Expo,” at which some 2500  information technology professionals participated in a 12-track program featuring more than 200 presentations on scientific and technologic developments.

From  keynote speakers Jill Mesirov, PhD, and Martin Leach, PhD,  respectively the Associate Director and Chief Information Officer  of the Harvard-MIT Broad Institute,  I learned that exponential increases  in computing power promise to bring personalized medicine –allowing highly individualized diagnosis and treatment –to doctors offices within ten years. I also learned how hard it is to keep track of the petabytes  ( a PBs is a unit of information equal to one quadrillion  bytes, or 1024 terabytes )  used to keep it all going.

Mesirov announced the upcoming launch of “Genome Space“–a new Web-based technology to help scientists make sense of and collaborate in using such data.

And in a talk entitled “BIG,”  Leach described the difficulty of defining “big data,” because the amount of available information is growing so rapidly.   He described an event held recently at the Broad to celebrate the Institute’s ability to store and analyze ten pedabytes of data –his glee soon tempered by  his recollection that in 1993, NIH’s Institute of Medicine was thrilled with its ability store 16 gigabytes–which anyone can now do on a cell phone.

Today,  Leach said, we are  seeing “increasing big data with a decreasing footprint.” [that is, smaller systems needed for gathering and retrieval].

Mentioning that he has an autistic son and would like to be able to figure out what causes the disorder, Leach  asked, “Why is there no Google search for data, no way to access thousands of data repositories?

“We need a new application ecosystem and a breed of data scientist who knows how and where to push this data, ” he said.  He predicted that there will soon be 50 thousand jobs in the  “big data” arena.

In the exhibit hall,  I was pleased to see that  see that Wingu, headquartered in the Cambridge Innovation Center, where I work, had been nominated for a best of show award for its pharmaceutical, contract research and academic collaboration software.

The winners, announced last night, were Recentris, Opscode, Clear Trial, and Cambridge Semantics. [More info at http://www.bio-itworld.com/2012/04/26/2012-best-of-show-winners.html]. Best Practice Grand Prizes went to big Pharma: Merck, Pfizer, and Merck KGaA (Germany)  went to and two genomics organizations, BGI Shenzhen and the University of Utah/Omicia. http://www.bio-itworld.com/2012/04/25/bio-it-world-announces-winners-2012-best-practices-awards.html.

BIO-IT World is sponsored by  Insight Pharma Reports, Samsung, and the Portland Group. It runs through April 27, 2012.

—Anita M. Harris

Thought you might like to know that my client, Scientia Advisors, is offering five free Webinars aimed at helping major corporations, emerging companies and innovative startups choose strategic directions.

The Webinars, in February, 2009, will present Scientia’s latest industry reviews. The reviews are based on interviews with scientists, clinicians, manufacturers, and product developers as well as on traditional market research.

The Webinars will initially be presented live, with opportunities for interactive participation.  Less-detailed Webcasts will subsequently be available for download from the Scientia Advisors Web site.

Here’s the schedule; click on any of the titles for more information or to register.
Anita

· Riding the High Value In Vitro Diagnostics Wave: Translating Promise Into Clinical Reality With Managing Partner Harry Glorikian, 11 AM Tuesday, February 10

· Back to the Future: Cell Market Entrance Strategies, Post-Stem Cell Deregulation

With Partner Arshad Ahmed, 11 AM Wednesday, February 11

· Drivers of Success in Functional Foods
With Principal Bob Jones 2 PM Wednesday, February 11

· Molecular Diagnostics: Identifying Candidates for Success in an Innovation-Driven Market

With Harry Glorikian, 11 AM Thursday, February 12

· Point of Care: Enabling Broad Product Adoption Through Maximized Access to Health Care Sites
With Harry Glorikian, 11 AM Thursday, February 19

Scientia Advisors, based in Cambridge, MA and Palo Alto, CA, is an international management consulting firm specializing in growth and operational strategies for major and emerging companies in health care, life science and biotechnology.

New Cambridge Observer is a publication of the Harris Communications Group, of Cambridge, MA.

Cambridge consulting firm Scientia Advisors says that big pharma could begin to reap profits from personalized medicine much sooner than predicted by marketing new diagnostics tools along with drugs that are already on the market. (Most pharma companies are currently using personalized medicine tools only in developing new drugs–which won’t bring any profits for years down the road).  Based on quantitative and qualitative research, Scientia’s study, published in the January, 2009 Pharmaceutical Executive describes how  three companies grew their profits and improved their relationships with prescribing physicians using the new model.  According to Scientia Managing Partner Harry Glorikian, the method will also improve patient care, lower costs and lead to health system reforms.  More info is available at www.scientiaadv.org.

Scientia Advisors is a client of the Harris Communications Group.

Anita Harris