I recently interviewed Bob Langer–MIT biotech guru extraordinaire–on behalf of the EBD Group, which holds international partnering conferences for the life sciences six times a year.  Here’s the opening…and a link to the rest, on the EBD Site. The piece will also  appear in xconomy shortly. Full disclosure…Bob is a personal friend, former classmate, and a member of the Harris Communications Group advisory board…so this should be considered a sponsored post.

–Anita M. Harris

When Bob Langer joined the MIT faculty in 1977 he had a rocky start. Trained as a chemical engineer and working on drug delivery systems, many of his ideas went against conventional wisdom. “I had people write the most insulting things about my knowledge of biology and medicine. Many thought my ideas were crazy. A number of professors wanted me to leave and my first nine grant proposals were turned down.”

Eventually, after numerous academic scientists and companies repeated and used his work Langer was able to get grant funding from the NIH. He also turned to companies for research funding—in return for licensing his patents—which, at that time, also went against the conventional grain.

Today, Langer is one of 13 Institute Professors (being an Institute Professor is MIT’s highest honor) at Massachusetts Institute of Technology. With more than 1,400 articles to his credit, he is the ninth most cited individual in history, according to Google scholar. (Sigmund Freud is first). His 1,300 patents, licensed or sublicensed to more than 350 companies in pharmaceutical, chemical, biotechnology and medical device fields, have led to more than 100 products currently in use or in clinical trials. He has received more than 220 major professional awards including the Queen Elizabeth Prize for Engineering, Priestly Medal, National Medal of Science, National Medal of Technology and Innovation, the Charles Stark Draper Prize (considered the equivalent of the Nobel Prize for engineers), and the Lemelson-MIT prize for being “one of history’s most prolific inventors in medicine.” In June 2018, he was named a US international envoy for science by the US State Department.

Despite his success, Langer remains well aware of his early setbacks, and, as a scientific advisor to some 200 companies over the past 40 years, is highly cognizant of what can go wrong.

“You can have bad animal results, failed trials, or patent problems. I’ve seen partners pull out, companies take bad loans, and the FDA create delays. Stumbling blocks can arise anywhere along the way,” he says.

One of the most difficult problems can occur early on “when a researcher has good findings but is not far enough along for investors or companies to want to spend a lot of money.” In that situation, known as “the valley of death,” Langer says, “the question is how to get enough data so that will change.”

More: 

Anita M. Harris is a writer and communications consultant based in Cambridge, MA.

New Cambridge Observer is a publication of the Harris Communications Group, also in Cambridge.

MIT, Convergence Idea Challenge

For the  last few months, I’ve had the opportunity to work on an amazing national report about the Convergence of technologies in the life sciences. The goal of the report–which will be launched this coming Friday at the National Academy of Sciences, in Washington, DC– is to encourage  increased  funding for engineers, mathematicians, physicists, chemists, and information technologists for work in health and life science fields.  More on the report and Convergence later this week.

For now, I want to let you know that Nobel Prize winning scientist Phil Sharp of the MIT Koch Institute  has offered a $3000 award for the best Convergence idea submitted by students across the US–and that the public is invited to help choose  a second, $1000 “community” winner—-by “liking”  ideas submitted via on Facebook.  The goal is to challenge  emerging researchers to combine the life/physical sciences, information technology, social sciences, and engineering to improve human health.The voting deadline is 6 pm on Thursday, June 23, 2016.

Here’s a list of the submissions–which come from researchers across the US.  More info on each idea–and “like” options– are available at https://www.facebook.com/ConvergenceIdeas/

• Hex House; a rapidly deployable, dignified home
• A Multi-disciplinary Approach to Tackling Childhood Poverty
• Biomarkers and Neural Circuits Underlying Resilience to Stress
• Neuroprosthetics in Nerve Reanimation: Implantation of Intraneural Building
• Beyond Biology Breast milk – mine of potential therapies
• Getting VacSeen-ated Mobile Screening and Diagnostics
• Engineering Pro-Regenerative Immunotherapies
• Empowering HIV-positive Youth in Swaziland, Africa: A Novel Digital Mentorship Experience
• Development of minimally invasive assessment of placenta across gestation
• An Epidemiological Cellular Automata Model of Gun Violence
• Transforming Clinical Data Into Field-Deployable Medical Apps
• Engineering a Flexible Organic Photovoltaic Cell as an Artificial Retina to Restore Sight: A Promising Vision in Bio-nanoelectronics
• Accelerating translation from bio-discovery to engineered applications by single cell niche sequencing
• Using Nature’s Fundamental Choice Against it
• Drinking Water Health – Intermittent Water Supply in Developing Countries
• “Brain train” – optogenetic cognitive-conditioning for neuropsychiatric disorders
• Sparsh- Sleeping Bag
• Quantified ethology decreases time to diagnosis of infection
• Interlocking culture system for resolvable three-dimensional cell arrangements
• A New Treatment for Depression through Modification of Semantic Networks in the Brain Using a Computer Game

–Anita M. Harris
New Cambridge Observer is a publication of the Harris Communications Group, a marketing and communications firm based in Kendall Square, Cambridge, MA.

With three days to go, the kickstarter campaign for BTW (Behind the Walls)  –a multi-platform media company devoted to beautiful, healthy, energy efficient and sustainable home, .is 85% funded.  Led by our friend and Cambridge Innovation Center colleague Harold Simansky, BTW needs $3K to get to $25K tor will take in nothing at all. I hope you’ll support the project. Here’s a link to the kickstarter site:

Harold writes:

Environmentally sound, healthy homes can be as stylish as they are sustainable; as beautifully designed as they are responsible; as glam as they are green… and a lot less expensive than you might think.

Now that eco-awareness is (finally and thankfully) skyrocketing, the country has exploded with new ideas for the home—everything from innovative, energy-saving technologies and home automation systems to products, decors, and furnishings that are toxin-free, sustainable and beautiful. Now you can live a green life at home without having to choose between what’s eco-friendly and what’s style-friendly, what’s efficient and what’s expensive.

BTW is here to keep homeowners on the cutting edge, building a community that shares our vision of healthy, energy-efficient and sustainable building and renovation practices, met with beautiful design. We’re also here to educate the community about service providers and funding—in the form of thousands of rebates and incentive programs—to make that possibility a reality. We want to make it clear that living a healthy, energy-efficient, and happy green lifestyle is within reach… and it all begins in the home.

What We Do

We’re creating a vibrant community of forward-thinking homeowners with BTW: Behind the Walls, a multi-platform media company that combines a magazine (both print and online), a website, social media, videos, blog posts, creative events, and—soon to come—podcasts and ecommerce, to help consumers envision and create a new kind of home and lifestyle.

Our goal is to help all homeowners understand, as they undertake some 20 million home improvement projects every year, how to do it more efficiently, more stylishly, greener, and healthier, using the best products, services and funding.

https://www.kickstarter.com/projects/959029715/btw-the-magazine-of-beautiful-healthy-and-sustaina?ref=home_featured

–Anita M. Harris
Anita Harris is a writer and communications consultant in Cambridge, MA.
New Cambridge Observer is a publication of the Harris Communications Group, an award-winning PR and digital marketing firm based at the Cambridge Innovation Center, in Cambridge, MA.

Our colleague Seth Taylor asked us to let you know that BioTechTuesday will be holding a $22K Life Science Innovation Competition and Pitch event on November 19; deadline to enter the competition is Tuesday, Nov. 12.

Here’s the scoop:

BiotechTuesday, a networking organization for life science professionals, will hold an innovation competition at which major pharmaceutical and biotechnology companies will award $22K in funds and in-kind services.   The winners will be life-science startups and researchers judged to have the most innovative ideas and laboratory products.

The event will take place at District Hall, a new event space at 75 Northern Avenue in the Boston Seaport District, from 6-9, on Tuesday, November 19.

Awards include:

• Financial and in-kind prizes for the most promising startup concepts and early stage ventures. Innovators can submit their concept or venture online for consideration by November 12, 2013. The BiotechTuesday community will then vote online—contributing to the selection of five finalists who will pitch their concepts at the event. At the event, competition judges from Novartis, EMD Serono, Pharmatek and others, will choose the winners.  CLICK HERE TO ENTER[http://goo.gl/gBhiaq]

• Recognition for the most innovative recently-launched products or services. Companies can submit recently launched products or services online for consideration, by November 12, 2013.  Finalists will present their pitches one-on-one to attendees and judges at the event.  CLICK HERE TO ENTER [http://goo.gl/03Q7pG]

“This competition event is unique in that it relies on a true community from a top life-science super cluster to select and validate some of the most exciting new approaches in the field,” said Seth Taylor, BiotechTuesday co-founder and host. “It provides a tremendous opportunity for the community to engage with innovators launching the hot companies of the future, and products that may impact their work today.”

Peter Parker, co-founder and director of programming for LabCentral, an innovative, shared laboratory space designed as a launchpad for life-sciences startups, said: “We share in Biotech Tuesday’s mission to advance innovation in the life-sciences community. We are pleased to offer one month’s free membership and a bench space in LabCentral’s co-working lab and office facility ($4,000 value). LabCentral provides fully functional lab space, permits, waste handling, plus all reasonably common lab equipment for bioresearch. Access to conference rooms and event space,  kitchens, etc. is also included, as is participation in programming specific to the interests of life-sciences startups.”

In the words of Charles Wilson, Vice President and Head of Business at Novartis Institutes for Biomedical Research, Inc:  “We believe that the time and expertise of large companies can be of great value to startups.  For this reason, we have committed to offering resources and analysis to help a winning company reach investors and commercialize their therapeutics.”

Timothy Scott, President and Co-Founder, Pharmatek Inc., a contract research organization offering $3000 in reagents to the winning team, said:  “We are committed to supporting innovation with our products and services, and through our Pharmatek University educational programs,”

Event attendance is open to the public. Click here to register [http://goo.gl/fRUh1J].

BioTechTuesday is a networking organization offering monthly events and an online community for life science professionals.  Founded in 2002 in the Boston area, BiotechTuesday now has thousands of members. 

Contact: Seth Taylor 617-615-6152    staylor@biotechtuesday.com   Twitter: #pitchbio

New Cambridge Observer is a publication of the Harris Communications Group, an award-winning PR and market development firm specializing in strategic communication, media relations, social and digital media for health care, life science, biotech, tech and energy.  

Kendall Square 4-17-13

Despite a historically strong anti-development bias in Cambridge, the City Council last week approved a new zoning law that will allow further transformation of the already growing Kendall Square. The new law, passed on April 8, approves plans for a new gateway to MIT facing the Kendall Square MBTA Station, the construction of some 1.1M square feet of new commercial space around the T stop, and hundreds of new housing units. (More details at  HarrisCom Blog:   http://wp.me/p1Hocg-Wy            ).

According to Tim Rowe, president of the Kendall Square Association and a founder of the Cambridge Innovation Center,  while, at last week’s meeting,  many Cantabridgians questioned the desirability of new buildings that could create traffic noise, “construction hassle and the like”, others emphasized the importance of innovation and entrepreneurship

“They spoke about how these endeavors are critical to our prosperity in these days of intense competition with other regions, how they bring jobs to residents all across the state, and how the fruits of the labors of our innovators and entrepreneurs are solutions to important problems facing the planet,” Rowe said. “What is super exciting to me is that our political leaders, by their vote, accepted these arguments.  This is a major win for innovation.”

In a blog posted to clients of the Cambridge Innovation Center–including me–Rowe emphasized that the Kendall Square community concerned about sustainability–as evidenced that  “despite millions of square feet of new buildings being built here” during the past decade, traffic in Kendall Square has actually dropped.

Rowe emphasized the need for additional state funding to ensure that the Red Line can keep up with demand in Kendall Square and urged his readers to tell their state senators and representatives to support Governor Deval Patrick’s proposal to invest  heavily in updating the Commonwealth’s transportation infrastructure.

Having worked in the Cambridge Innovation Center for nearly three years, I can attest to the vibrancy and vitality of this growing area.

–Anita M. Harris

New Cambridge Observer is a publication of the Harris Communications Group, an award-winning public relations and digital marketing agency located in Kendall Square.

The Cambridge Innovation Center, (CIC) where I work,  has signed a new lease for 52,000 square feet of space on the 1st, 14th and 15th floors at 101 Main Street in Cambridge. 101 Main Street is two doors down from CIC’s current home at One Broadway. The new location is owned by RREEF Real Estate, the real estate investment business of Deutsche Asset Management.

CIC has already vastly expanded since I first started working there in the Spring of 2010; currently, some 450 companies and 1700 people rent space on seven floors.

According to a recent communiqué from the CIC, “ We have seen strong continuing interest from the CIC community to grow here in Kendall Square, as well as interest from many others not currently located at CIC. This new space will create increased space options and amenities for our current and future clients and most importantly, the space will create more opportunities for entrepreneurs to collaborate and flourish.

This is a 33% increase in the CIC”s  total space — to a total of 207,000 square feet in Kendall Square. Occupancy of the new space will begin in early March.

With the expansion, I hope that  the  stellar CIC team and residents will be able to maintain the warm,  friendly and stimulating community atmosphere that makes the CIC at 1 Broadway a wonderful place to work.

Anita M. Harris

Anita Harris is the founder and CEO of the Harris Communications Group, a collaborative team of experts  in public relations, social media, content and marketing services for health, science, technology and energy, worldwide.

Sorry I couldn’t make it to this year’s Global  Cleantech Meetup but am pleased to post information provided  by Harold Simansky about his company, 360 Chestnut , which provides resources for consumers and service providers  in the home improvement market, and about WeFunder, a crowd investing platform for startups.

Both companies are headquartered at the Cambridge Innovation Center in Kendall Square, where I share space, although I have not yet met either Simansky or WeFunder cofounder and President Mike Norman.

Simansky says the two companies “stole the show,” but I’ll bet they got a run for their money (so to speak) from my friend and informal PR client,  Christine Adamow, who announced that her company, EuphorbUS,  which has produced pure fuel oil from tree seeds in Africa since 2007, is setting up shop in Hawaii. [Link to Euphorbus release.]

Simansky writes that WeFunder is the premier crowd investing platform for startups, while 360Chestnut is growing into one of the largest home improvement sites on the web.

Both startups were featured presenters at the  two day conference: Norman gave the keynote address to the more than 500 attendees and Simanski spoke on home improvement and sustainability.

Simansky points out that 360Chestnut is using the WeFunder  platform to raise its most recent round  of  investment, and in his  keynote, Norman called  360Chestnut an “ideal company” to use crowd investing to fund its growth.

Simansky describes WeFunder as “a crowd investing platform for startups.”  Using the platform, crowd investors can purchase stock for as little as $100 in promising new businesses around the country.  With the passage of the  US JOBS Act in April,  startups will soon be allowed to solicit investment from small, “unaccredited” investors and sell small stakes in their businesses online.

He says that  360Chestnut is “a no-cost, trusted source” where homeowners learn what to do to make their homes more healthy, energy-efficient and comfortable;  connect with qualified service providers, and access the more than 5000 rebate and incentives that will pay for this type of work.

For service providers, 360Chestnut is “a constant source of educated, nurtured customers; marketing & sales support; easy-to-use software and applications; online training; financing options and more.   Service providers pay to join and may purchase products and service son the site.

–Anita M. Harris

New Cambridge Observer is a publication of the Harris Communications Group, an award-winning public relations and online-marketing firm based in Cambridge, MA.

        Later today, I hope to attend the Clean-Tech Meetup–an event which,  Gov. Deval Patrick, has said, “brings together innovative leaders from across the Commonwealth, the country and the globe to grow businesses, advance technologies and expand the adoption of clean energy sources.”

             As described on the Clean Tech Meetup Web site,  “through  Clean Energy Week and the Conference on Clean Energy in Boston,”  Massachusetts has been “steadily growing” a community of clean energy innovators and implementers.   “Now, we’re using what we’ve learned to bring you an event focusing on connecting people in intimate settings—instead of panels or keynotes.”

• Major Energy Consumers, Utilities, Leading Cleantech Companies, and other companies looking to form partnerships will meet providers of innovative clean energy services, products, and technologies.
• Investors will meet over 50 companies from more than 10 countries, hear from emerging clean energy companies, and talk with major energy users about their needs for clean energy technologies.
• Emerging Clean Energy Companies will talk with potential investors, strategic partners, and customers.

View the conference program.

Innovation Tour:  The conference also includes a tour of “cool companies and organizations” that will be holding open houses”from  Kendall Square to the Seaport Innovation District,” on Wednesday.  View the Tour participants.

I’m pleased that my friend and informal client, Christine Adamow, President and CEO of EuphorbUS,   announced today that her company, , a  “tree-based”  biofuel company that  has operated in East Africa since 2007,  will soon open its first operating site in North America in Hawaii.

The Meetup  is pricey, with registration $400+ for  participants and  $500-$1000 for presenters, who are selected by the conference organizations. (Might say I was surprised that the organizers called the event a meetup– because most “meetups” I’ve heard of are free or nearly so).   Held at the Boston Convention Center, it  runs through Wednesday.

—Anita M. Harris