Governor Deval Patrick and Medicon Valley Officials after signing collaboration agreement at 2012 Bio International Convention on 6/20/12. Photo by Anita Harris, Harris Communications Group.

“It’s not about what we can give you or take; it’s about how we can share.” So said Massachusetts Governor Deval Patrick before signing a collaboration agreement with officials from Medicon Valley MOU –located in the Capital Region of Denmark, Region Zealand in Denmark and Region Skåne in Sweden. The  agreement was one of two  partnerships signed today between Massachusetts and European regions. The second was with Catalonia, Spain.  Both  agreements were signed at the BIO International Convention.

“Our innovation economy is thriving here in Massachusetts and establishing and encouraging international partnerships is an important part of our future growth,” Governor Patrick said. “Catalonia and Medicon Valley are important regions in Europe’s innovation sector, and these partnerships will allow us to move forward on our mutual goals in this part of the global economy.”

The Medicon Valley memo of understanding (MOU) was signed by Governor Patrick and officials from the Capital Region of Denmark, Region Zealand in Denmark and Region Skåne in Sweden.

The agreement focuses on enhancing research partnerships in life sciences by an exchange of researchers and students; identifying special projects, partnerships or collaborations that can lead to new or enhanced research opportunities; and establishing a framework to be used in joint projects that could be financed by the European Union or National Institute of Health to develop new products and processes that can be used in the global market, according to a press release furnished by the governor’s office.

Medicon Valley is a bi-national region composed of the island of Zealand in eastern Denmark and the Skåne region of southern Sweden. It is home to over 200 companies in biotech, med-tech, and pharmaceuticals with over 350 additional companies in those fields having affiliate or branch offices in the region. These industries employ 40,000 people.

The MOU with Catalonia, Spain was signed by Governor Patrick and the President of Catalonia, Spain Artur Mas I Gavarro, with U.S. Ambassador to Spain Alan Solomont present for the signing. The Patrick-Murray Administration has partnered with the Catalan Government to put real collaboration into a renewed agreement on the 20^th anniversary of Lieutenant Governor Paul Cellucci signing a Declaration of Intent of Cooperation in 1992 between Massachusetts and Catalonia, according to the release.

The agreement facilitates collaboration in the following areas:

a)         Bilateral cooperation in research, and technological and industrial innovation;

b)         Business cooperation and economic development in key productive sectors, especially in life sciences, renewable energy, information technology, advanced manufacturing and infrastructure, and;

c)         Academic cooperation.

Catalonia has pursued a policy similar to Governor Patrick’s of investing in the innovation economy. Areas of convergence include the life sciences, mobile devices, clean energy technology, and advanced infrastructure. In 2011, Spain was Massachusetts’ 21st largest export partner, with Massachusetts exporting approximately $326.99 million worth of goods and services.

The BIO International Convention provides Governor Patrick, Lieutenant Governor Timothy Murray, state and industry leaders with an opportunity to showcase Massachusetts as a global leader in the life sciences industry, and the preeminent place for life sciences companies to invest in and expand. On Tuesday, Governor Patrick announced the first round of grants awarded under the Massachusetts-Israel Innovation Partnership (MIIP). MIIP is a formal collaboration between the State of Israel and the Commonwealth of Massachusetts to encourage and support innovation and entrepreneurship between Massachusetts’ and Israel’s life sciences, clean energy and technology sectors. A total of at least $1.3 million is being awarded to four research & development (R&D) collaborations between Massachusetts and Israeli companies that have been jointly approved by the funding agencies on both sides. The total budget of the awarded projects is estimated at approximately $3 million. The Massachusetts awardees are located in Natick, Needham, North Billerica and Wilbraham.

Earlier on Wednesday, the Governor joined seven global biopharmaceutical companies to announce the formation of the Massachusetts Neuroscience Consortium. Participating companies include Abbott, Biogen Idec, EMD Serono, Janssen Research & Development, LLC, Merck, Pfizer and Sunovion Pharmaceuticals Inc. The Consortium will fund pre-clinical neuroscience at Massachusetts academic and research institutions.

Governor Patrick’s ten-year, $1 billion life sciences investment package has strengthened the state’s global leadership in the life sciences. The initiative melds all of the state’s key resources in order to spur research, investment, innovation and commercialization. Now the life sciences industry in Massachusetts is thriving, with more than 52 percent job growth in the biopharma sector since 2001 and more than 80,000 employees working in the life sciences.

–Anita M. Harris
New Cambridge Observer is a publication of the Harris Communications Group, an award-winning  public relations and marketing communications agency located in Cambridge, MA.

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BOSTON — Wednesday, June 20, 2012 — Seven global biopharmaceutical companies have each pledged to contribute $250,000 a new consortium that will fund preclinical neuroscience research in order to accelerate and make available academic research from Massachusetts to the pharmaceutical industry, Massachusetts Governor Deval Patrick and consortium members announced today.

Companies participating in the Massachusetts Neuroscience Consortium include Abbott, Biogen Idec, EMD Serono, Janssen Research & Development, LLC, Merck, Pfizer and Sunovion PharPmaceuticals Inc.

“From Alzheimer’s disease, to Parkinson’s disease, to multiple sclerosis, neurological diseases affect millions of Americans and millions more across the globe,” Patrick said. “Through the research that this consortium will fund, we aim to bring those people, their families, and many others hope for a better future.”

The announcement took place in the Massachusetts Pavilion at the 2012 BIO International Convention.

According to a press release from the governor’s office: the Consortium is a pioneering new model designed to leverage Massachusetts’ rich environment for purposes of accelerating early-stage research available to the pharmaceutical industry, introducing academic researchers to the challenges of targeted research, and facilitating industry-academic collaborations.

A number of factors make the Massachusetts Neuroscience Consortium unique:

• Proposed projects will be short-term and results-oriented. Timelines, milestones, budgets and objectives will be clearly defined by the industry sponsors.

• Industry sponsors will identify common standards, e.g. levels of validation necessary for a project objective to be considered “complete.”

• Industry sponsors will work in collaboration with principal investigators and their teams; sponsors also will contribute tools, data and other resources to the project teams to expedite their work.

• Results are shared with all participants; companies and academic researchers will have access to the use of any tools developed by each project; industry sponsors will determine their interest in validated targets as projects are completed.

“The Consortium is a pioneering new model that is designed to leverage the rich research environment in Massachusetts for purposes of accelerating pre-clinical research available to the biotech and pharmaceutical industry, introducing academic researchers to the challenges of targeted research, and facilitating industry-academic partnerships,” said Susan-Windham Bannister, Ph.D., President and CEO of the Massachusetts Life Sciences Center. “I sincerely thank our seven charter members for stepping up to this challenge and joining in this new collaboration.”

Each participating company has pledged to contribute $250,000 to the Consortium, for total initial funding of $1.75 million. Members of the Consortium will solicit and review proposals from academic research institutions for pre-clinical neuroscience research. The first solicitation is expected to open in the fall of 2012. All Massachusetts academic and research institutions will be eligible to apply for grant funding through the Consortium. The Massachusetts Life Sciences Center will administer the Consortium, and will use its convening power to reduce barriers to collaboration and to expedite access to the research community.

Massachusetts is a center of excellence in the field of biomedical neuroscience with world leaders representing all major fields of neurobiology and neurology. The combination of basic neuroscience, translational and clinical research across more than a dozen world-renowned institutions represents what may be the world’s highest density of neuroscience research. This provides a rich and fertile environment within which to advance the understanding and treatment of brain disorders.

“EMD Serono is proud to be a part of this new initiative to further neuroscience research within our company’s home state of Massachusetts,” said James Hoyes, President of EMD Serono. “This Consortium represents true collaboration amongst industry leaders, to foster breakthroughs in science today that will change the shape of medicine for tomorrow. We look forward to accelerating research and innovation in the area of neuroscience, and together, making a difference in the lives of patients.”

“Janssen Research & Development is pleased to be a charter sponsor of this innovative approach to advance neuroscience research,” said Husseini Manji, MD, Global Therapeutic Area Head, Neuroscience, Janssen R&D. “We believe scientific collaboration that brings together the best ideas and expertise from both academia and industry will play an important role in helping translate basic science discoveries into promising new treatments.”

“We are delighted to be a founding member of the Neuroscience Consortium,” said Douglas E. Williams, Ph.D., Executive Vice President, Research and Development at Biogen Idec. “New types of collaborations among academia and industry are increasingly important to stimulating the discovery of better therapies and advancing science and medicine. At Biogen Idec, we are working on discovering and developing drugs across a number of areas in neurodegenerative disease and believe that this first-of-its-kind collaboration among the state, biopharmaceutical companies and top academic researchers is important for maintaining a vibrant and innovative research organization and making sure we deliver better therapies to patients with these difficult diseases.”

“Pfizer Neuroscience is in Cambridge, Massachusetts, largely due to the intense concentration of neuroscience thought leaders,” said Dr. Michael Ehlers, Chief Scientific Officer for Pfizer Neuroscience. “This collaboration is a step forward in our effort to address the urgent need for therapies in neurologic and psychiatric disease.”

“This is an exciting and promising new model for collaboration to advance the study of behavioral health and neuroscience disorders. Sunovion is proud to participate in this initiative,” said Richard Russell, Executive Vice President and Chief Commercial Officer, Sunovion Pharmaceuticals Inc. “The Life Sciences Center has played an essential role in convening this group and making this collaboration happen, and we thank them for their leadership.”

“The academic research community is committed to understanding these neurologic conditions at the most basic and fundamental molecular level, and most importantly, to translating that depth of understanding into clinical application,” said Jeffrey S. Flier, Dean of Harvard Medical School. “Basic discovery and translational science are essential to our success, and we in academia have the infrastructure to do it.”

“When I was first diagnosed with MS nearly 20 years ago, there were no approved treatments on the market,” said Joann D’Amico Stone of Waltham. “Since that time, there have been tremendous advancements made, opening up a number of options for patients – including my MS treatment from Biogen Idec. It’s heartening to see these companies collaborating, because I think that it will ultimately help speed and increase the number of important treatments that can benefit patients like me.”

“In 2009 I became the fourth member of my extended family to be officially diagnosed with Alzheimer’s Disease,” said Allen Krieger of Lexington, a distinguished astrophysicist. “Alzheimer’s has changed my life in a number of ways – I have difficulty finding things, making decisions, and remembering things that used to be routine. I’ve participated in clinical trials and other research to do what I can to help. This consortium is a new and promising approach to advancing Alzheimer’s research through collaboration between the companies and academic institutions that are leading the way in the search for a cure.”

“We are in a race against time in our fight to find treatments and a cure for Alzheimer’s,” said James Wessler, President and CEO of the Alzheimer’s Association, MA/NH Chapter. “We applaud Governor Patrick and the Massachusetts Life Sciences Center for the foresight shown in the creation of this new neuroscience consortium. For the 120,000 people in Massachusetts with Alzheimer’s, this cannot come soon enough.”

The BIO International Convention provides Governor Patrick, Lieutenant Governor Timothy Murray, state and industry leaders with an opportunity to showcase Massachusetts as a global leader in the life sciences industry, and the preeminent place for life sciences companies to invest in and expand.

Governor Patrick’s ten-year, $1 billion life sciences investment package has strengthened the state’s global leadership in the life sciences. The initiative melds all of the state’s key resources in order to spur research, investment, innovation and commercialization. Now the life sciences industry in Massachusetts is thriving, with more than 52 percent job growth in the biopharma sector since 2001 and more than 80,000 employees working in the life sciences.

–Anita M. Harris

New Cambridge Observer is a publication of the Harris Communications Group” , an award winning public relations and marketing communications firm based in Cambridge,

CNN host Fareed Zakaria said yesterday that despite the world’s current economic and political difficulties,   he is optimistic about the future  but that it is by no means clear “who will be winners and the losers”  in what he called a “new global landscape.”

In a keynote talk at the Biotechnology Industry Organization International Convention in Boston,  Zakaria said, that the world is currently “extraordinarily  peaceful” compared with previous decade and that it is quite “unified, with a global economic system, interactive communications and technology and greater computing power than ever before.  (For example,  the cell phone has more computing power than did the Apollo spacecraft capsule in 1969. ” It could go to the moon, he said, but it could not tweet,”  he quipped. )

In the past, he said, the US has always been able to emerge from  economic difficulties  due to its tremendous capacity to innovate–and in the second half of the twentieth century, maintained a substantial economic and innovative edge over other nations.  But, he said, “we forget that at other times, other countries have  had the edge.”    He asked, “Will the US  maintain its edge?”

Zakaria outlined what he called three distinct historical  phases or causes that, he said, account for the US’  “extraordinary” lead:

(1) During World War II, the forces of destruction had a huge spillover effect.  Germany, a major US competitor, was “leveled to the ground” and England was bankrupted.

(2) During the Cold War, fears of losing out to the USSR in the 1950s  led the US government to make double the investment in US companies than it is making now;  government purchases of US computers and components accounted for the lion’s share of profits for those companies, until the cost curve began to decline. What is more, the government invested heavily in higher education, so that citizens could obtain the world’s finest education in public universities” without paying a cent”

(3) “The third pillar was Jews ” he said. “If  Hitler had not made the morally reprehensible to target Jews, the US would not have had the influx of scientists who created the bomb, transformed theoretical physics and gave the US a 30-year lead.”

What this shows, he said,  is that America’s propensity of innovate is “not due to DNA,” but rather, that there are specific historical reasons why the US took a commanding lead.

Today, he said, there is a new global landscape  in which it is possible for smaller nations– such as Denmark, where  the Global company Novo Nordisk, known for its diabetes treatments,  was founded–  to be at the leading edge in certain technologies.

What is more, Zakaria pointed out,  innovation does not necessarily correlate directly with spending for research and development.  Apple is often considered one of the most innovative companies in the world–but that is because it understood consumers and  how to create a new need,  rather than because it offers the most cutting edge technology, he said.  “Big company and big country advantages no longer hold, going forward.”

On a panel following the talk, Kiran Mazumdar-Shaw, founder and chair  of the Indian biotechnology company Biocon, said that the current process of biotechnology development is unsustainable and most products are too expensive to benefit most of those who need them.  “Countries in Asia must reinvent the process of drug innovation,” she said.

Greg Lucier, CEO of Life Technologies, which supplies systems, biological reagents and services to enable scientific research, said that  new genomics tools will be the stimulus to streamline innovation, cut costs,  and change the future of  human health.

Derek Hanekom,  South Africa’s Deputy Minister of Science and Technology emphasized the importance of  government’s role in providing access to care and sanitation. Governments can promote innovation by recognizing and supporting it,  reducing unnecessary regulations yet adding regulations to promote competition, and supporting  education to develop a skilled workforce.

Yucel Altunbasak, president of Tubitak, the Scientific and Technological Research Council of Turkey, listed financing, talented people, regulatory framework, and a governmental support mechanism as keys to helping emerging markets do “what the US did in the 1950’s.”

Four Massachusetts-Israeli business collaborations have received a total of $1.3M in grant funding under the  Massachusetts-Israel Innovation Partnership (MIIP)–a  formal collaboration between the State of Israel and the Commonwealth of Massachusetts to encourage and support innovation and entrepreneurship between Massachusetts’ and Israel’s life sciences, clean energy and technology sectors.

The grants were announced yesterday at the  2012 BIO International Convention in Boston by Massachusetts  Governor Deval Patrick and  Israeli Chief Scientist Avi Hasson, of  MATIMOP, the  Israel Ministry of Industry, Trade and Labor.

The four winning projects are:

• SBH Sciences (Natick) and Improdia (Israel) will work together toward the development and manufacture of a chronic inflammation-dependent immunosuppression prognostic kit. SBH will receive $184,000 from the Center and Improdia will receive $202,000 from Israel’s OCS.SBH Sciences is a discovery and preclinical contract research organization with expertise in production and analysis of cytokines and biomarkers. Improdia is a life science start-up focused on implementing novel biomarkers for immune system modulating therapies– using  simple blood tests for patients with chronic disease.

•  Automated Medical Instruments (AMI – Needham) and STI Lasers (Israel) will develop new technology involving radio frequency energy to perform circumferential ablation of the pulmonary veins. AMI will receive $116,000 from the Center and STI Lasers will receive $110,000 from OCS. AMI is a start-up medical device company developing novel technology to perform atrial fibrillation treatment. STI Lasers is a medical device company specializing in laser cutting, micromachining and finishing of miniature metal components.“AMI is developing the CircumBlator™,  to offer a reliable and curative, minimally invasive treatment for millions of patients with atrial fibrillation, a disease that causes over 20 percent of strokes and untold misery,” said Martin Sklar, President and CEO of Automated Medical Instruments.

• Lantheus Medical Imaging, Inc. (North Billerica) and Check-Cap (Israel) will  develop a novel 3-D imaging capsule that can be used to screen for polyps and lesions associated with colorectal cancer. Lantheus will receive $300,000 from MTC and Check-Cap has been selected to receive at least an equal amount from OCS. Lantheus  develops, manufactures and distributes innovative diagnostic imaging agents. Check Cap is a medical device company located in Mount Carmel, Israel with a “breakthrough” solution for Colorectal Cancer Screening.  “As a global leader in diagnostic imaging, Lantheus is dedicated to providing physicians with breakthrough new tools to enhance patient care. Teaming up with Check-Cap to develop and manufacture a cutting-edge imaging capsule further advances this ongoing commitment,” said Don Kiepert, President and CEO, Lantheus Medical Imaging.

• FloDesign Sonics (Wilbraham) and Transbiodiesel (Israel)  will use FloDesign’s acoustic molecule separation technology to separate oil that can be used to create fuel from Transbiodiesel’s oil-generating algae. FloDesign Sonics will receive $55,000 from MassCEC and Transbiodiesel will receive $20,958 from OCS. FloDesign Sonics uses a novel ultrasonic acoustophoretic separation technology developed at Western New England University for a more efficient approach to wastewater treatment and micro-algae harvesting for biofuels. Transbiodiesel is a start- up company with a novel technology for producing biodiesel fuels from a variety of oils

The MIIP program was first announced in June 2011 at the BIO International Convention in Washington, D.C. and the first joint solicitation for proposals was launched in September 2011 by MATIMOP on the Israeli side and by the three participating Massachusetts agencies: the Massachusetts Life Sciences Center, the Massachusetts Technology Collaborative (MTC) and the Massachusetts Clean Energy Center (MassCEC). Total funding for the current projects is approximately $3m.

The partnership came as a result of a 2011 trade mission in which  Governor Patrick and a coalition of Massachusetts business executives and senior government officials explored growth opportunities of common interest for Massachusetts’ and Israel’s innovation industries. During that mission Governor Patrick and Shalom Simhon, Israeli Minister of Industry, Trade and Labor, signing on behalf of their respective states, signed a Memorandum of Understanding (MOU) in Jerusalem. MIIP was established to implement the MOU’s framework.

Massachusetts is the first U.S. state to establish a significant industrial R&D program with the State of Israel, according to a press release issued yesterday by Patrick’s office.

Today there are nearly 100 companies with Israeli founders or Israeli-licensed technologies in Massachusetts, according to the release.  In 2009, these companies employed nearly 6,000 people and generated $2.4 billion in direct revenue for the state. Local firms exported over $180 million worth of goods to Israel in 2009. Home to 377 hospitals and 37,000 practicing physicians, Israel is an important market for health-related technologies.

The New England-Israel Business Council, the US-Israel Science and Technology Foundation, the Government of Israel Economic Mission to North America, the Consulate General of Israel to New England and MOITI have all played an important role in promoting the program, according to the release.

–Anita M. Harris

New Cambridge Observer is a publication of the Harris Communications Group, an award-winning strategic public relations,  marketing communications and thought leadership firm in Cambridge, MA.

PRESS RELEASE

· New antibody program targets Tau protein, a major cause of Alzheimer’s disease

· License agreement potentially worth more than Swiss Francs 400 Million (approximately USD 418 million*)

Lausanne, Switzerland, 18 June, 2012 – AC Immune SA, today announced that it has entered into a second exclusive worldwide license agreement and research collaboration with Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY) for the research, development and commercialization of AC Immune’s anti-Tau antibodies for the potential treatment of Alzheimer’s disease and other neurodegenerative diseases.

Under the terms of the agreement, AC Immune will receive an undisclosed upfront payment and is eligible to receive research, development and commercialization milestone payments totaling more than Swiss Francs 400 million (approximately USD 418 million*) for Alzheimer´s disease and other indications. Additionally, AC Immune is eligible to receive royalties on net sales of products resulting from the collaboration. Under the multi-year joint research collaboration, AC Immune will work in partnership with Genentech to identify and formulate several pre-clinical candidates. Genentech will have global responsibility for pre-clinical and clinical development, manufacturing and commercialization of antibodies resulting from the collaboration.

Prof. Andrea Pfeifer, CEO of AC Immune said: “We are delighted to continue our excellent relationship with Genentech through this second landmark deal to fight Alzheimer’s disease. This underlines Genentech’s trust in AC Immune’s proprietary technology platform and we are confident in our joint abilities to develop not only
first-in-class but also best-in-class medication for one of the biggest healthcare problems of this century.”

“This second licensing deal gives us financial security to continue AC Immune’s
world-leading efforts to develop disease modifying therapies and diagnostics. We are now recognized as having one of the broadest and most advanced Alzheimer’s pipelines in the industry”, remarked Martin Velasco, Chairman of The Board of AC Immune .

Commenting on the deal, James Sabry, Genentech’s Vice President of Partnering , said: “Genentech is committed to bringing innovative treatments to patients suffering from devastating neurodegenerative diseases, and is developing a number of approaches to tackle Alzheimer’s disease. The addition of this anti-Tau program to our CNS pipeline complements other approaches we are investigating, including crenezumab which we in-licensed from AC Immune in 2006.”

About the anti-Tau Program

The Tau protein forms twisted fibers inside brain cells and build tangles that are considered by many in the scientific community as the second major cause of Alzheimer’s disease besides Abeta-plaques. The anti-Tau antibodies were discovered and humanized by AC Immune through its proprietary SupraAntigen TM technology.

“The anti-tau-antibodies have proven highly specific to misfolded Tau in relevant animal models for Alzheimer’s disease and are therefore well suited to be developed as a disease-modifying drug. This has significant potential as there are at present no known cures for Alzheimer’s disease,” said Dr. Andreas Muhs, Chief Scientific Officer
of AC Immune .

About Crenezumab

An anti-Abeta antibody, crenezumab was discovered and humanized by AC Immune. It is designed to bind to amyloid beta (Abeta), the main constituent of amyloid plaque in the brains of patients with Alzheimer’s disease. Abeta is considered to be a major cause in the development of the disease. Genentech is currently evaluating crenezumab in a Phase II clinical study in Alzheimer’s patients with mild to moderate symptoms. At the time the deal with Genentech was announced in December 2006, it was stated to have a potential total value of more than USD 300 million in clinical and regulatory milestone payments to AC Immune, excluding royalties.

In May 2012, crenezumab was selected to be tested in the world’s first-ever prevention trial in healthy individuals who are genetically destined to develop Alzheimer’s disease. This landmark study to investigate whether an anti-amyloid treatment can stave off the disease is being run by the US National Institutes of Health (NIH), the Banner Alzheimer’s Institute (BAI), the University of Antioquia in Colombia and Genentech.

About Alzheimer’s Disease

Alzheimer´s is the most common form of dementia. It is degenerative, irreversible and terminal. The memory and thinki ng of the patients is progressively destroyed. Besides the personal aspect there is a huge social and economic impact. Alzheimer´s disease is recognized as a significant health crisis of the 21st century with currently more than
36 million patients worldwide. This number is expected to double in the next 20 years and to triple to more than 116 million by 2050. In 2010 global worldwide costs were estimated to be USD 604 billion and were exceeding 1% of the global domestic product (Reference: World Alzheimer Report 2011, Alzheimer’s Disease International).

Scientists don’t yet fully understand what causes Alzheimer’s disease, but it has become increasingly clear that it develops because of a complex series of events that take place in the brain over a long period of time. Two proteins – Tau and Abeta – are perceived as the major causes of neurodegeneration: tangles and other abnormal forms of Tau protein accumulate inside the brain cells, while plaques and oligomers formed by Abeta occur outside the brain cells of people with Alzheimer’s disease.

About AC Immune SA
AC Immune SA is a Swiss-based biopharmaceutical company and a leader in Alzheimer´s disease drug development. AC Immune develops innovative therapeutics with “best in class” potential against Alzheimer´s disease and other conformational diseases along three axes: vaccines, antibodies and small molecules. The anti-Abeta antibody (crenezumab) for passive immunization is partnered with Genentech and is in Phase II development. The company continues to develop in house the small molecule ACI-91 and the vaccine ACI-24 in Phase II and Phase I/IIa clinical development respectively. These three clinical programs are focused on Alzheimer’s disease, and are backed by a rich portfolio of preclinical compounds. The therapeutic molecules are also leveraged for Alzheimer´s disease diagnostic and other central nervous system and non-CNS diseases, such as Glaucoma. Since its foundation in 2003, AC Immune has raised CHF 64 million from private investors.

-Anita M. Harris
Disclosure: I will be working with AC Immune at the Biotechnology Industry Organization today in Boston.

New Cambridge Observer is a publication of the Harris Communications Group, an award-winning strategic public relations,  marketing communications and thought leadership firm in Cambridge, MA.

Four Boston-area startups were among those showcased  in an international program on collaborative cancer research & therapy clusters held today at the Whitehead Institute in Kendall Square, Cambridge.

All four of the Boston companies are developing methods and technologies that aim to better diagnose or cure cancer; all are hopeful; all are seeking funding, investors, or purchasers.

The program, called the International Cancer Cluster Showcase,  was sponsored by Sanofi, which recently purchased Cambridge-based Genzyme  Corporation, and by cancer  research and treatment clusters in the Norway, the UK, France and  in Massachusetts.

The program was held in conjunction with the International Biotechnology Industry Organization (BIO) Convention, to start tomorrow.

In introducing the Boston area companies, Abigail Barrow of the Massachusetts Technology Transfer Center,  who chaired  the Boston and the overall sessions,  pointed out that Cambridge is, perhaps, the paramount biotechnology and cancer research center in the US.

• AcuityBio, Inc. a Boston University Spinoff,  is developing a  biodegradable polymer mesh  to be implanted during cancer surgery for later, sustained use in local administration of cancer drugs, according to John Schwartz, the AcuitBio CEO.  The goal is to  prevent cancer recurrences in specific soft tissues thus improving the quality of patients’ lives, recucing the cost of care, increasing the length of disease-free progression and sigificantly improving cure rates for early stage cancer patients,  Schwartz said.

• Joel Beriac, PhD, the president & CEO of Akrivis Technologies said that his company is developing an ultrasensitive ” Z-Tect,” (TM) technology platform that promises to allow much earlier cancer detection and more effective personalized therapies than is currently possible. Z-tect will save numerous lives and reduce healthcare costs by lowering “several thousand fold” the current limit-of-detection of early cancer biomarkers, imaging much smaller cancer lesions. Akrivis plans to ultimately develop, beyond ultrasenstivie diagnostics, safer and more efficacious targeted therapies.

• BIOARRAY Therapeutics  is developing molecular diagnostics to improve cancer treatment decisions that are currently made on a trial-and-error basis, according to  Marcia V. Fournier, PhD, the BIOARRAY founder and CEO.  BIOARRAY’s core technology identifies relevant cancer biomarkers based on the normal biology and micro-environment representing underlying biological processes involved in the progression of tumors– independent of any specific patient set, cancer subgroup or treatment, Fournier said. The company’s lead diagnostic is a response prediction test for breast cancer–targeting the growing molecular diagnostics and personalized medicine markets.

• CanThera Therapeutics is a development stage oncology therapeutics company built on technology from the Mass General Hospital laboratories and the Broad Institute.  According consultant Peter Leone, the investigators have found that a natural substance, piperlongumine (PL) appears to kill cancer cells by jamming the machinery that dissipates high oxidative stress (ROS). Normal cells have low levels of ROS and don’t need high levels of the antioxidant enzymes that PL stymies. CanThera aims to advance a selected novel analog of PL into the clinic in 2012.

The showcase also featured:

QUEBEC PRESENTERS:

• Angiochem:     www.angiochem.com          

Q-CROC (Quebec – Clinical Research Organization in Cancer)    http://qcroc.ca      

OSLO PRESENTERS:

• Epitarget AS:       www.epitarget.com               
•  Lytix Biopharma:   www.lytixbiopharma.com          
• Targovax AS:    www.targovax.com       
• Vaccibody AS: www.vaccibody.com    

TOULOUSE/CANCER BIO SANTE CLUSTER PRESENTERS

• Carlina Technologies: www.carlinatech.com     
• Millegen: www.millegen.com
• Skuldtech: www.skuldtech.com      
  

UK PRESENTERS

• Senectus Therapeutics Limited: www.senectustherapeutics.com   

• Acublate  Limited

Poster Session Companies

Oncocat: www.oncocat.org/principal.php?idiom=eng

AB-therapeutics: www.ab-therapeutics.com

Oryzon: www.oryzon.com/es/inicio 

–Anita M. Harris

New Cambridge Observer is a publication of the Harris Communications Group, an award-winning strategic public relations,  marketing communications and thought leadership firm in Cambridge, MA.

UK-based Alacrita, a global life science consulting firm with consultants worldwide, will soon be opening an office in Cambridge, MA, according to Robert Johnson, who will head the office, here.

The company was co-founded two years ago by Anthony Walker, who had previously served as Executive Director of Global External R&D Europe at Eli Lilly,  and  by Johnson, who had led business development at Onyvax, a biotech company that developed biopharmaceuticals to combat cancer.

Drawing on the capabilities of more than 50 consultants worldwide, Alacrita  provides strategic, operational,  technical  advice or  hands-on project management to organizations of all sizes in  the pharma, biotechnology and life science industries, Johnson said.

According to the Alacrita Web site, clients may be academic institutes, tech transfer experts,  life science investors, startups  or  established companies in need of expertise in:

• Business development and marketing
• Intellectual property
• Product development
• Regulatory affairs

Recent whitepapers available on the  company Website   include:

• Biotech in Israel: A Land of Promise » May 2012 – by Anthony Walker, PhD
• FDA Approvals Provide Reason For Cheer » March 2012 – by Robert Johnson
• Deal Watch Annual Review 2011 » January 2012
• Viewpoint: Pharma Industry Myths » January 2012 – by Anthony Walker, PhD
• Europe’s stellar decade of prostate cancer innovation » September 2011 – by Rob Johnson
• Are we all biotech now? » June 2011 – by Anthony Walker and Rob Johnson
• China: Opportunities for biotech firms » March 2011 – by Rob Johnson and Li Zeng
• Re-Profiling: a Hidden Threat to Originators? » February 2011 – by Dr Jo Davies
• Deal Watch Annual Review 2010 » January 2011 – by Roger Davies and Jill Ogden
• Mitigating Out-sourcing Risk » December 2010 – by Robert Johnson and Anthony Walker
• Deal Watch: a Review of Notable Deals » October 2010 – by Sharon Finch

Alacrita’s US offices will be located in the Cambridge Innovation Center in Kendall Square.  The company name comes from the Latin, “alacritas,” or “lively.”  It is meant to convey “a cheerful readiness,” Johnson said.

–Anita M. Harris

New Cambridge Observer is a publication of the Harris Communications Group, an award-winning strategic public relations,  marketing communications and thought leadership firm in Cambridge, MA.